Medical Director, Respiratory Translational Medicine

Responsibilities

• Lead design and delivery of translational and early clinical plans for respiratory programmes, including proof‑of‑mechanism and proof‑of‑concept studies.
• Leverage disease expertise to translate pre‑clinical and human biomarker data into clinical hypotheses, endpoints and go/no‑go decision criteria.
• Provide medical and scientific leadership on cross‑functional project teams and clinical governance forums.
• Define biomarker strategies and oversee their implementation, including sample collection, analysis and interpretation.
• Support regulatory interactions and prepare clinical sections of regulatory documents and briefing materials.
• Mentor and coach colleagues to build capability in translational and clinical development.
• Ensure patient safety through oversight of medical monitoring and alignment with pharmacovigilance.
• Partner with external experts, academic collaborators and clinical sites to accelerate evidence generation.
• Contribute to portfolio prioritisation by evaluating clinical feasibility, risks and potential patient benefit.
• Drive clear, timely communication of translational findings to project teams and stakeholders.

• Medical degree and clinical medical specialty training board qualification/registration.
• Experience in the global pharmaceutical/biotechnology industry in the field of respiratory medicine.
• Experience in translational medicine and clinical development in respiratory or related therapeutic areas.
• Experience designing and delivering early‑phase clinical or experimental medicine studies.
• Experience with biomarkers, sample strategy and interpretation of translational data.
• Cross‑functional collaboration experience working in matrix teams.
• Experience with regulatory interactions for early clinical programmes.
• Medical degree and clinical medical specialty training board qualification/registration in Pulmonary Medicine/Pulmonary & Critical Care.
• Experience in multimodal data analysis to support deep disease insights.
• Hands‑on experience novel early‑phase study approaches.
• Track record of publications or conference presentations in translational respiratory science.
• Excellent written and verbal communication skills for diverse scientific and non‑scientific audiences.
• Experience managing external collaborations with academic or clinical networks.

PLEASE NOTE:

This career opportunity requires an on‑site office presence (minimum of two days a week) in one of GSK's UK (London - New Oxford Street or Stevenage) sites.

The Respiratory, Immunology and Inflammation Research Unit (RIIRU) was formed in 2024 to identify and advance novel molecular targets with genetic associations to disease based on the foundational observation that targets with human genetic evidence supporting their causal role in the intended indication improves clinical success by two‑fold. The remit of RIIRU is to identify novel targets based on human genetics, develop assets for clinical studies, and perform trials through to submission for approvals.

This goal is enabled through strategic external (e.g., Flagship Pioneering, Vesalius, Muna Therapeutics and others) and GSK‑internal partnerships (Research Technologies).

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process, contact us at UKRe