Director, Clinical Science – Oncology Clinical Development

Director, Clinical Science – Oncology Clinical Development

Cancer is unrelenting, but so are we. At GSK, we are committed to transforming outcomes for people with cancer through innovative science, bold ambition, and strong partnerships across the healthcare ecosystem. We focus our science where it can matter most—advancing care in cancers with high unmet need, grounded in a deep understanding of disease biology and deliberate scientific choices that connect discovery to meaningful impact in the real world.

• Provide scientific leadership across defined components of study-level activities, including protocol development, study design, data review, and interpretation, within the strategic direction set by the CDL
• Serve as a core member of the Clinical Matrix Team (CMT), ensuring scientific alignment across study objectives, timelines, and deliverables
• Provide scientific insight to the CDL and Senior Scientist to inform asset‑level strategy, benefit‑risk assessment, and programme‑level decision‑making
• Ensure the scientific quality and consistency of key clinical and regulatory documents, including protocols, Investigator’s Brochures, Clinical Study Reports, and submission materials
• Apply scientific and clinical expertise to analyse and interpret data, ensuring rigour, integrity, and relevance to the target patient population
• Engage with internal and external stakeholders, including investigators and Key External Experts, to support study execution and scientific exchange
• Contribute to a culture of scientific excellence, innovation, and continuous improvement within Oncology Clinical Development

• Provide scientific input into protocol development and study design, ensuring robustness, feasibility, and alignment with CDP-defined objectives and regulatory requirements
• Author or co‑author key study documents (e.g., "Clinical Study Proposals"), contributing to preparation and presentation at governance forums such as Protocol Review Boards
• Support study conduct by addressing scientific questions, ensuring data integrity, and maintaining alignment with protocol and regulatory standards
• Provide scientific input into study‑level decisions related to protocol implementation and study conduct, within the strategic framework defined by the CDL
• Present and support the scientific rationale and study design at Investigator Meetings and respond to scientific inquiries from study sites
• Support implementation of study‑level Go/No‑Go criteria aligned to the asset‑level decision framework defined by the CDL

• Analyse and interpret clinical data to generate insights on safety, efficacy, and patient populations
• Integrate data from internal and external sources (e.g., literature, competitor data, emerging science) to inform study and programme understanding
• Provide scientific input into data review and interpretation activities, in collaboration with Medical Directors and pharmacovigilance
• Translate study findings into clear scientific insights to inform programme progression and support CDL‑led decision‑making

• Contribute to development of clinical and regulatory documents, including protocols, Investigator’s Brochures (IBs), Clinical Study Reports (CSRs), and submission materials
• Ensure scientific accuracy, consistency, and quality across study documentation
• Support preparation of regulatory submissions and responses to Health Authority queries
• Contribute to regulatory reporting requirements (e.g., DSURs, INDSRs) and ensure alignment with regulatory standards

• Serve as a core member of the CMT, partnering with Clinical Operations, Statistics, Safety, Regulatory, and Medical Affairs to support integrated study delivery
• Provide scientific expertise to cross‑functional discussions, including integrated evidence planning and disease‑area forums, as appropriate
• Participate in internal and external scientific interactions with investigators, Key External Experts, advisory boards, and collaborators
• Contribute to scientific communications,…