Director, Business Operations; Global Quality Control

Overview

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

What We Do Is Every Bit As Important As How We Do It! Our Work Together Is Guided By Four Enduring Core Values. RETHINK CONVENTION, AIM HIGH, LEAD WITH HEART, MODEL EXCELLENCE.

• RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.
• AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.
• LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.
• MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

The Director, Business Operations (Global QC) will lead the strategic design, implementation, and continuous optimization of global operational frameworks supporting Vaxcyte’s Quality Control (QC) and supporting Analytical interfaces. This role ensures that analytical inputs and QC operations are scalable, compliant, efficient, and aligned with corporate and regulatory expectations as the organization advances from development through commercial readiness.

The Director will serve as the central business operations leader for the Global Quality Control, partnering with leaders in Analytical Development, Analytical Science & Technology, Stability, Process Development, Manufacturing Science and Technology (MS&T), and Quality. This individual will drive governance, process standardization, infrastructure development, and cross-functional coordination to enable timely, compliant, and uninterrupted supply of Vaxcyte’s innovative vaccines.

• Operational Excellence & Strategy
• Lead the design and execution of operational strategies that translate Vaxcyte’s global vision into efficient, compliant, and scalable QC and analytical business operations.
• Develop and maintain a global QC operations strategy, ensuring alignment with clinical and commercial objectives.
• Implement continuous improvement frameworks (e.g., Plan-Do-Check-Act) to enhance efficiency, scalability, and compliance across analytical and QC processes.
• Define and monitor key performance indicators (KPIs) that assess operational performance, quality, delivery timelines, and cost efficiency across the global analytics network.
• Partner with cross-functional leaders to ensure analytical and QC infrastructure, systems, and processes are integrated into overall business objectives.
• Lead initiatives that improve operational automation, data visibility, and process robustness.
• Governance & Compliance
• Establish and maintain robust governance frameworks for QC and analytical operations in alignment with global cGMP regulations and internal quality standards.
• Define, visualize, and formalize QC business processes using RASCI principles, ensuring clear ownership and accountability across the analytical network.
• Review and enhance the Quality Management System (QMS) infrastructure to close gaps, harmonize SOPs, and strengthen procedural consistency.
• Ensure data integrity principles are embedded in all operational practices, compliant with Vaxcyte’s DI policies and global standards.
• Support global inspection readiness and lead preparations for regulatory inspections, partner audits, and customer reviews.
• Collaborate with Quality to ensure analytical operations and contract testing laboratories meet all compliance requirements.
• Infrastructure & Systems Leadership
• Oversee the development and…