Scientist, Analytical and Biological Mass Spectrometry; ABMS

Position: Scientist, Analytical and Biological Mass Spectrometry (ABMS)
Build our future together:

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a highly motivated Scientist to join our Analytical and Biological Mass Spectrometry (ABMS) team in support of Regeneron R&D programs. In this role, you will work in a collaborative mass spectrometry laboratory focused on the biochemical characterization of emerging therapeutic modalities and monoclonal antibodies across all stages of development.

This position offers an opportunity to contribute to a fast-growing, science-driven organization while learning through hands-on project work and making a meaningful difference for patients worldwide.

When & where:

Full-time position based at Regeneron’s Tarrytown headquarters

Requires a minimum of four days per week onsite

Discover your role:

Develop and optimize primarily LC-MS-based analytical methods to support diverse R&D programs, applying sound scientific judgment and demonstrating a clear understanding of the methods and experiments performed

Analyze and interpret LC-MS data using appropriate software and bioinformatics tools to characterize the quality attributes of therapeutic proteins and emerging modalities

Support R&D activities and regulatory submissions while expanding organizational knowledge of antibody therapeutics and other emerging modalities

Independently perform sample preparation and LC-MS-based experiments according to SOPs, and document experiments, results, and conclusions in electronic laboratory notebook (ELN) entries

Present data at group and project meetings, and prepare technical reports, SOPs, and regulatory submission documents

Summarize results clearly and concisely using graphs, figures, and tables to support presentations, peer-reviewed publications, and regulatory documents

Communicate with integrity, honesty, and respect in written and verbal interactions; contribute openly to scientific discussions and raise questions or concerns when appropriate

Take ownership of experimental work, openly discuss unexpected results, identify root causes, and make timely corrections while maintaining accurate and transparent records

Learn new technologies and scientific concepts through active participation in projects, collaboration with colleagues, and constructive feedback, while contributing enthusiastically in a team environment

This role requires:

BS or MS (or higher) in chemistry, biochemistry, analytical chemistry, pharmaceutical sciences, metabolism, or a related field6–8+ years of industrial or academic experience in the analytical characterization of small molecules, antibodies, protein therapeutics, AAVs, metabolites, lipids, or other therapeutic modalities

Knowledge of and hands-on experience with LC-MS-based sample preparation for cells, tissues, biological matrices, and drug substances

Strong knowledge of metabolism and hands-on experience in metabolomics or lipidomics are highly desirable; experience with metabolic flux analysis, isotope tracing, or related quantitative approaches is a plus Knowledge of pharmaceutical formulation and process development is a plus Knowledge of and experience in AAV virology, siRNA, and structural biology are a plus

Experience with automated liquid-handling systems (Biomek, Bravo, King Fisher, Tecan, or similar platforms) is a plus

Experience with specialized LC-MS-based techniques, such as hydrogen-deuterium exchange mass spectrometry (HDX-MS), ion mobility spectrometry-mass spectrometry (IMS-MS), and quantitative proteomics, is a plus

Experience with experimental design and data analysis, including design of experiments (DoE), molecular modeling, graphing, statistical analysis, or quantitative pathway and flux analysis software, is a…