Postdoctoral Research FELLOW; Miraldi - Computational Immunobiology

Overview

Dr. Miraldi’s Immuno-Engineering Laboratory seeks a computational research fellow to build mathematical models of the immune system in vivo. These models will be constructed from high-dimensional immune-system measurements (e.g., single-cell genomics, chromatin state, proteomics). Our modeling frameworks span mechanistic (e.g., dynamic gene regulatory networks) to deep learning (e.g., prediction of cellular epigenomes from DNA sequence). Situated at Cincinnati Children’s Hospital, we design computational methods and systems-immunology studies that will improve the health of children.

Through collaboration with physician and experimental colleagues, we iteratively test and refine our models so that the models yield novel insights into immune-cell function and guide new therapeutic strategies in autoimmunity, infectious disease and cancer. The ideal candidate will collaborate closely with experimental immunologists, physicians and other computational biologists. The team will design and execute hybrid computational-experimental strategies that push the boundaries of both immunology and computational biology.

• Design, execute, and record laboratory experiments, and analyze the data.
• Research and improve current methods and evaluate innovative techniques. Implement this knowledge in the Division/Department.
• Present research at laboratory meetings, journal clubs, seminars, and meetings.
• Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants.
• Maintain currency in field through continuing education, literature, and seminars.
• Attend required Cincinnati Children’s training sessions and ensure regulatory compliance with all policies and procedures.
• Perform other duties as assigned.

External

Required: Ph.D. in related discipline, MD, or equivalent degree

Preferred: The ideal candidate will have a quantitative background in computational/systems biology, engineering, computer science, statistics, math, or a related field. He or she will also (1) be a fluent programmer in at least one language (e.g., Python, R, MATLAB) and be willing to develop fluency in other languages, as needed, (2) have research experience in machine learning, bioinformatics and/or mathematical modeling, and (3) a trackable publication record.

An enthusiasm and willingness to develop immunology expertise on the job is also necessary.

Primary Location
:
Location S

Schedule
:
Full time

Shift
:
Day (United States of America)

Department
:
Immunobiology

Employee Status
:
Regular

FTE
: 1

Weekly Hours
: 40

• Medical coverage starting day one of employment.
• Competitive retirement plans
• Tuition reimbursement for continuing education
• Expansive employee discount programs through our many community partners
• Shift Differential, Weekend Differential, and Weekend Option Pay Programs for qualified positions
• Support through Employee Resource Groups such as African American Professionals Advisory Council, Asian Cultural and Professional Group, EQUAL - LGBTQA Resource Group, Juntos - Hispanic/Latin Resource Group, Veterans and Military Family Advocacy Network, and Young Professionals (YP) Resource Group
• Physical and mental health wellness programs
• Relocation assistance available for qualified positions

* Benefits may vary based on FTE Status and Position Type

At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a holistic team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.

Cincinnati Children's is:

• Recognized by U.S. News & World Report as a top 10 best Children’s Hospitals in the nation for more than 15 years
• Consistently among the top 3 Children’s Hospitals for NIH Funding
• Recognized as one of America’s Best Large Employers (2025), America’s Best Employers for New Grads (2025)
• One of the nation's America’s Most Innovative Companies as noted by Fortune
• Consistently certified as a great place to work
• A Leading…