Senior Principal Scientist | Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead

Senior Principal Scientist | Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead page is loaded## Senior Principal Scientist | Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead remote type:
Flex Commuter / Hybrid locations:
US - California - Thousand Oaks:
US - California - South San Francisco time type:
Full time posted on:
Posted Todayjob requisition :
R-234045##
** Career Category
** Scientific## ##
** Job Description**## Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
** Senior Principal Scientist - Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead**##
** What you will do
** Let’s do this. Let’s change the world. In this vital role you will add to our diverse team in Pharmacokinetics & Drug Metabolism – Bioanalytical Sciences (PKDM-BA) to advance our growing siRNA research portfolio. You will lead the strategy and execution of innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples, both in vitro and in vivo, for characterizing ADME and elucidating pharmacokinetics and pharmacokinetic-pharmacodynamic relationships.

In addition to leading teams within PKDM-BA, you will be a project team representative contributing to multidisciplinary teams composed of experts in chemistry, biology, toxicology, clinical pharmacology and the like to drive clinical candidate selection and successfully file regulatory applications.
* Lead strategy to establish innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples (in vitro and in vivo)
* Lead strategy to establish innovative in vitro ADME assays for antibody-siRNA conjugates
* Design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, tissue distribution, and toxicokinetics of antibody-siRNA conjugates
* PKDM-BA project team representative for antibody-siRNA conjugates and other siRNA modalities
* Lead and execute on preparation of the pharmacokinetic written summary for regulatory applications
* Mentor and cross-train PKDM-BA scientific colleagues
* Build and foster cross-functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept##
** What we expect of you
** We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.
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* Basic Qualifications:

** Doctorate degree [and relevant post-doc where applicable] in pharmacology, biochemistry or a related-scientific discipline and 3 years of industry experience## OrMaster’s degree in pharmacology, biochemistry or a related-scientific discipline and 6 years of industry experience## Or Bachelor’s degree in pharmacology, biochemistry or a related-scientific discipline and 8 years of industry experience
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* Preferred Qualifications:

*** Extensive knowledge of antibody-siRNA conjugate ADME and pharmacokinetics;

Experience with respect to other siRNA modalities, antibody-drug conjugates, peptide conjugates, biologics and/or small molecules is also highly desirable
* Experience investigating biodistribution and metabolism of siRNA conjugated to a tissue-targeting ligand
* Expertise in antibody-siRNA bioanalytical approaches and…