Senior Principal Scientist – Target Discovery & Biology; TD&B

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Principal Scientist – Target Discovery & Biology (TD&B)

Let’s do this. Let’s change the world. Amgen’s Target Discovery & Biology (TD&B) organization integrates functional genomics screening, multi-omics profiling, human genetics, and complex in vitro systems to uncover new biological insights and therapeutic targets. TD&B partners closely across Amgen’s therapeutic areas to translate data into discovery, accelerating the path to target discovery and prosecution.

We are seeking a highly motivated, innovative, and experienced Senior Principal Scientist based in Thousand Oaks to lead a team focused on the development, delivery, and implementation of complex in vitro models that help power target discovery and functional genomics efforts. In this essential role for discovery at Amgen, you will be part of a dynamic, cross-functional team to advance target and biological discovery across Amgen’s therapeutic areas.

In this vital role you will:

• Provide scientific and operational leadership for a team of scientists delivering advanced in vitro models and screening-ready systems in collaboration with therapeutic area partners.
• Guide the design, optimization, and screen implementation of cellular models that capture disease-relevant biology, integrating insights from disease tissue profiling data.
• Champion partnerships with automation colleagues accelerate model deployment and reproducibility.
• Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights.
• Identify and implement emerging technologies in cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms.
• Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline.

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR Pharm

D OR MD [and relevant post-doc where applicable] and 3 years of directly related experience

Master’s degree and 6 years of directly related experience

Bachelor’s degree and 8 years of directly related experience

Preferred Qualifications:

• Doctorate degree in cell biology, molecular biology, biomedical engineering, or related discipline.
• 6+ years of relevant experience in biotech or pharma, including leadership of scientific teams.
• Strong track record in complex in vitro model development, cell engineering, and high-throughput or automated screening
• Experience with high-content imaging and transcriptional assay readouts
• Demonstrated ability to collaborate with cross-functional teams to translate disease biology into experimental models.
• Experience with viral vector systems (AAV, lentivirus, or related technologies) for gene delivery and perturbation.
• Experience in leading or mentoring scientists, with proven success in project execution and team development.
• Familiarity with data-driven discovery approaches, including integration of genetic or multi-omics insights.
• Excellent organizational and…