Senior Scientist

##
** Career Category
** Scientific## ##
** Job Description
** Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
** What you will do
**** Inflammation Research - In Vivo Pharmacology Scientist .
** The Department of Inflammation Research is seeking a dedicated, driven and independent Principal Scientist (manager) to join the
* In Vivo
* Pharmacology (IVP) group as part of a fast-paced, integrated and interactive research group exploring therapeutics for Inflammation, Autoimmune, and Rare Disease programs. The successful candidate will be responsible for designing and executing experiments exploring and understanding the pharmacology of drug targets; generating, communicating pharmacology and preclinical data to support the progression of research projects, and providing technical expertise to therapeutic area scientists.

This role has the potential for managing up to one report initially, contribution to project teams, collaboration with therapeutic area scientists and teams at multiple Amgen sites.
** Accountabilities:
*** A driven, pro-active, independent, and enthusiastic scientist who wants to contribute to cutting edge science and serve patients in a highly productive team environment.
* Strong understanding of Immunology and Inflammation biology and principles.
* Willingness and curiosity to learn and explore new areas of research.
* Significant hands-on expertise in animal (mouse and rat) handling and
* in vivo
* techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy) preferred.
* Significant experience designing and executing concurrent
* in vivo
* preclinical inflammation and autoimmune disease models.

Experience with colitis (DSS, CD45RB
hi T cell transfer, IL-10 KO), lupus (NZB/W, MRL-lpr, Imiquimod), and arthritis (CIA, CAIA), GvHD models preferred. Experience in HS, PBC a plus.
* Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, quantitative RT-PCR, BCA protein measurements) preferred. Hands-on experience with multicolor flow cytometry including Spectral flow approaches and Immune cell populations is essential.
* Computer literacy, especially proficiency with Graph Pad Prism, Excel, PowerPoint and Word.
* Attention to detail, excellent organizational and communication skills, accurate & timely record keeping and data analysis are essential.
* Demonstrated track record of independent critical thinking and scientific achievement.
* Demonstrated experience in pharmacology and
* in vivo
* models of inflammation/Immunology.
* Ability to work in a flexible team-oriented environment.
*
* Basic Qualifications:

*** Doctorate degree OR
* Master’s degree and 2 years of drug discovery experience OR
* Bachelor’s degree and 4 years of drug discovery experience
*
* Preferred Qualifications:

*** PhD degree and post-doctoral training (or drug discovery experience) in the fields of  Immunology, inflammation autoimmune disease, or related disciplines. 3-5 years of management experience in industry or academia.
* Experience working on project teams leading in vivo contributions.
** Thrive
* *** What you can expect of us
** As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

The expected…