Sr Principal Scientist Target Discovery & Biology - Thousand Oaks, CA

Sr Principal Scientist Target Discovery & Biology - Thousand Oaks, CA

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Job Description

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Unless specifically stated otherwise, this role is "On‑Site" at the location detailed in the job post.

Let’s do this. Let’s change the world. Amgen’s Target Discovery & Biology (TD&B) organization integrates functional genomics screening, multi‑omics profiling, human genetics, and complex in vitro systems to uncover new biological insights and therapeutic targets. TD&B partners closely across Amgen’s therapeutic areas to translate data into discovery, accelerating the path to target discovery and prosecution.

Role

We are seeking a highly motivated, innovative, and experienced Senior Principal Scientist based in Thousand Oaks to lead a team focused on the development, delivery, and implementation of complex in vitro models that help power target discovery and functional genomics efforts. In this essential role for discovery at Amgen, you will be part of a dynamic, cross‑functional team to advance target and biological discovery across Amgen’s therapeutic areas.

In this vital role you will:

• Provide scientific and operational leadership for a team of scientists delivering advanced in vitro models and screening‑ready systems in collaboration with therapeutic area partners.

• Guide the design, optimization, and screen implementation of cellular models that capture disease‑relevant biology, integrating insights from disease tissue profiling data.

• Champion partnerships with automation colleagues to accelerate model deployment and reproducibility.

• Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights.

• Identify and implement emerging technologies in cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms.

• Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline.

Auto req

Minimum

Education Required:

Bachelors

Job Category:
Scientific Research & Development

Minimum Education

Bachelors

Additional Qualifications & Responsibilities

What we expect of you

The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications

• Doctorate degree (PhD, Pharm

D, or MD) AND relevant post‑doc where applicable AND 3 years of directly related experience.

• OR Master’s degree AND 6 years of directly related experience.

• OR Bachelor’s degree AND 8 years of directly related experience.

Preferred Qualifications

• Doctorate degree in cell biology, molecular biology, biomedical engineering, or related discipline.

• 6+ years of relevant experience in biotech or pharma, including leadership of scientific teams.

• Strong track record in complex in vitro model development, cell engineering, and high‑throughput or automated screening.

• Experience with high‑content imaging and transcriptional assay readouts.

• Demonstrated ability to collaborate with cross‑functional teams to translate disease biology into experimental models.

• Experience with viral vector systems (AAV, lentivirus, or related technologies) for gene delivery and perturbation.

• Experience in leading or mentoring scientists, with proven success in project execution and team development.

• Familiarity with data‑driven discovery approaches, including integration of genetic or multi‑omics insights.

• Excellent organizational and communication skills, with the ability to drive cross‑site collaboration in a matrixed research environment.

What you can expect of us

As we work to develop…