Senior Scientist - Cardiometabolic Disorders

What you will do Let’s do this. Let’s change the world. In this vital role you will be an ideator and drug hunter and are expected to conduct biology research and identify therapeutic targets in cardiometabolic disease that are tractable and offer the opportunity of delivering disease-modifying potential in patients. The proposal and advancement of drug discovery programs will be based on a sound and compelling scientific rationale that may include validation from human genetics and/or clinical studies.

Critical thinking, ingenuity, the ability to independently design mechanistic studies and conduct reproducible in vivo and in vitro pharmacology studies with high technical proficiency, excellent communication skills, integrity and the ability to work in a multi-disciplinary environment will be critical for this role. You will initially work at the bench and/or vivarium conducting in vivo and/or in vitro preclinical studies with a focus on osteoporosis and metabolic disease.

Over time, you will also demonstrate strong leadership skills and the ability to manage a team of scientists conducting drug discovery research. As part of the team, you will also support other new and existing drug discovery programs in the department to help advance the best assets in the Cardiometabolic Disorders portfolio.

• Conceptualizing and proposing therapeutic targets for the treatment of bone disease and cardiometabolic disease
• Designing and performing in vitro and/or in vivo experiments
• Independently performing data analysis and interpreting results
• Communicating scientific results through written and oral presentations
• Collaborating with teams from other functions in the company to advance therapeutic candidates
• Documenting studies in electronic laboratory notebooks and study reports.
• Advising colleagues in areas of expertise

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] OR Master’s degree and 3 years of experience in bone metabolism and bone disease OR Bachelor’s degree and 5 years of experience in bone metabolism and bone disease

• PhD with postdoctoral experience in bone metabolism and metabolic disease (industry experience is strongly preferred)
• Strong target ideation capabilities and critical thinking to enable discovery of innovative medicines for patients
• Exceptional in vivo and/or in vitro pharmacology skills and capability to independently design, implement and analyze studies with proper controls and generate reproducible high-quality data
• Technical mastery of general molecular biology and cell-signaling analysis techniques including immunoblotting, immunocytochemistry, RT-qPCR, immunoprecipitation, and ELISA
• Basic knowledge of statistical methods applied in a consistent and rigorous manner to all data sets generated
• Excellent written and oral communication skills and interpersonal skills that enable effective team interactions and communication of key data to all key stakeholders
• A strong ability to collaborate cross-functionally in a multidisciplinary environment is critical
• Capability to deliver high quality manuscripts, posters and presentations for internal and external peer-reviewed publication and conference attendance
• Understanding of human genetics and genomic data mining for target identification are a plus
• A high level of commitment to ensuring data reproducibility and data integrity

• From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
• The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors…