Director - Targeted Protein Degradation

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happy lives. Our award‑winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team.

Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. The Induced Proximity Platform (IPP) is advancing novel therapeutic modalities that leverage proximity‑driven mechanisms to modulate biology in ways not achievable with conventional approaches. By integrating expertise in chemical biology, protein degradation, molecular glues, computational sciences, proteomics, and translational biology, IPP is creating new opportunities to address high‑value targets and unlock transformative medicines for patients.

We are seeking an accomplished and visionary Director of Targeted Protein Degradation (TPD) to provide scientific leadership for Amgen’s targeted protein degradation strategy within IPP. Reporting directly to the Head of IPP, this individual will define and execute a bold scientific vision, build next‑generation capabilities, establish strategic partnerships, and drive innovation across the rapidly evolving field of induced proximity therapeutics.

The successful candidate will be a recognized leader in targeted protein degradation, chemical biology, or related disciplines, with a demonstrated track record of translating pioneering science into impactful drug discovery opportunities.

Build upon Amgen’s differentiated Induced Proximity Platform to define and execute a long‑term scientific vision for targeted protein degradation and proximity‑based therapeutics, expanding the reach of the degrader platform into new biological spaces, therapeutic opportunities, and modalities while strengthening Amgen’s leadership in next‑generation drug discovery. Establish a differentiated scientific strategy that identifies where degradation and proximity‑based mechanisms can uniquely address high‑value biological targets and disease pathways beyond the reach of conventional therapeutic approaches.

Drive innovation across the targeted protein degradation landscape, including molecular glues, heterobifunctional degraders, tissue‑selective degraders, event‑driven pharmacology, and emerging induced proximity modalities. Develop frameworks for identifying, evaluating, and prioritizing new biological opportunities enabled by targeted protein degradation and proximity biology. Anticipate emerging scientific, technological, and competitive trends and translate them into actionable platform strategies and capability investments. Serve as a key scientific advisor to Research leadership, influencing platform investments, capability development, and long‑range innovation strategy.

Foster a culture of scientific ambition, rigor, and innovation that expands the boundaries of what is considered druggable biology.

Define and build next‑generation capabilities required to enable…