Scientist - LC-MS Bioanalytical

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnesses drives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier live.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

What you will do

Lets do this. Lets change the world. This lab-based role supports the design, development, validation, and implementation of robust LCMS/MS bioanalytical methods for therapeutic modalities including small molecules, oligonucleotides, proteins, and other complex molecular entities. The initial focus is to expand discovery-stage support within PKDMBA, while maintaining flexibility to support GLP preclinical and regulated clinical activities as needed. The role will also contribute to modernization of automation and instrumentation to improve assay throughput and sensitivity, working closely with multidisciplinary research and development teams across Amgen.

• Plan, execute, and document quantitative LCMS/MS bioanalytical experiments.
• Develop and implement fit-for-purpose bioanalytical methods with rapid turnaround.
• Perform small- and large-molecule bioanalysis in nonclinical and clinical matrices, including plasma, urine, CSF, and tissues.
• Prepare biological samples using protein precipitation, solid-phase extraction, liquidliquid extraction, affinity capture, and related techniques.
• Organize, analyze, interpret, and present bioanalytical data with strong attention to data integrity and fidelity.
• Maintain complete, accurate, and concise documentation in electronic laboratory notebooks and other laboratory systems.
• Ensure data and records meet applicable regulatory expectations for global submissions and remain current with relevant industry guidance.
• Author and review study reports, analytical methods, SOPs, technical memos, and other regulatory-compliant documents.
• Communicate bioanalytical results to discovery and development teams; contribute to publications and present findings at scientific meetings.
• Support report quality control, effective time management, and clear cross-functional communication.
• Follow all safety, training, documentation, and site-specific procedural requirements.
• Perform routine laboratory housekeeping and operational support activities as needed.

We are all different, yet we all use our unique contributions to serve patients. The scientific professional we seek is a key contributor with these qualifications.

• Doctorate degree
• Or
• Masters degree and 2 years of relevant industrial/technical experience
• Or
• Bachelors degree and 4 years of relevant industrial/technical experience

• Prefer Bachelor's or Master's experience
• Prior experience in CRO or pharma/biotech strongly desired
• Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms as well as HRMS
• Experience with an array of analytical technologies that can accelerate bioanalysis inclusive of automation and/or micro-sampling
• Prior GLP and GCP experience.
• Demonstrated expertise in working with a variety of sample types (e.g., blood, plasma, serum, tissues, cerebrospinal fluid).
• Hands-on experience with automated or semi-automated sample preparation for LC-MS bioanalysis, including protein precipitation, SPE, affinity capture, and other high-throughput workflows, using platforms such as King Fisher APEX/FLEX, automated SPE systems, and robotic liquid handlers.
• Prior experience in bioanalytical (regulated) assay execution and transfer to CROs
• Must be willing to work in a fast-paced, multi-project environment with high workload demands, and consistently deliver high-quality results within established timelines.
• Demonstrated ability to resolve scientific challenges efficiently and prioritize…