Senior Scientist - Therapeutic Modality Assessment Surface Targets

Position: Senior Scientist - Therapeutic Modality Assessment for Surface Targets
** Join Amgen's Mission of Serving Patients*
* At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease, obesity and obesity-related conditions, rare diseases, inflammatory conditions and cancer.  As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

** Senior Scientist - Therapeutic Modality Assessment for Surface Targets*
* ** What you will do*
* Let's do this. Let's change the world. Amgen's Surfaceome Platform is advancing the discovery and validation of cell type-specific surface targets across multiple disease areas, enabling the development of targeted therapeutics through a deeper understanding of cell-surface biology.

To support this mission, the Surface Biology early validation group focuses on triaging proteomics- and transcriptomics-derived hits to define actionable target properties and guide early therapeutic modality selection. We are seeking a Senior Scientist with biotechnology or pharmaceutical industry experience and a demonstrated track record of evaluating cell-surface targets across multiple therapeutic modalities.

In this role, you will conduct quantitative surface target characterization and apply your understanding of modality-specific mechanisms and requirements to propose and experimentally evaluate therapeutic modalities for surface targets, guiding target prioritization and early therapeutic strategy.

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* Key Responsibilities:

Scientist*
* + Propose therapeutic modalities for surface targets based on target properties and modality-specific characteristics. Define experimental strategies to assess the suitability of the proposed modalities for these novel targets.

+ Develop, standardize, and execute scalable, high-throughput quantitative workflows to evaluate how proposed therapeutic modalities affect surface protein degradation, internalization, trafficking, and downstream cellular function following target engagement.

+ Integrate experimental findings into rigorous Go/No-Go decision packages, identifying opportunities and limitations to guide therapeutic modality selection.

+ Collaborate closely with colleagues within the early validation team and across functions to address evolving project needs, rigorously document experimental workflows, and present high-quality, validated data in cross-functional team discussions.

** What we expect of you*
* We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a collaborative, critical-thinking scientist with these qualifications.

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* Basic Qualifications:

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* Doctorate degree (Ph.D.) [and relevant post-doc experience where applicable]

OR

Master's degree and 2 years of relevant scientific experience

OR

Bachelor's degree and 4 years of relevant scientific experience

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* Preferred Qualifications:

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* Qualifications:

+ Ph.D. in Cell Biology, Biomedical Science, Immunology, Oncology, Pharmacology, or a related biological discipline, with 2+ years of biotechnology or pharmaceutical industry research experience.

+ Demonstrated experience contributing to discovery programs across multiple therapeutic modalities, with experience in early target validation, antibody/binder or small-molecule characterization, and experimental assessment of therapeutic approaches for cell-surface targets.

+ Understanding of modality-specific characteristics, with the ability to propose therapeutic modalities and design experiments to evaluate their effects on target biology and cellular function.

+ Demonstrated scientific independence, broad knowledge of cell-surface biology, and a strong record of scientific contributions to therapeutic discovery programs.

+ Experience developing and executing high-throughput cell-based screening assays.

+ Hands-on experience measuring cell-surface target density, internalization, trafficking…