Senior Scientist - siRNA Therapeutics

Career Category Research Job Description At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease, obesity and obesity-related conditions, rare diseases, inflammatory conditions and cancer.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team.

Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this role you will join the Genetic Medicines team in Thousand Oaks, CA. As a new member of this team, you will be responsible for generating and implementing novel methods to deliver RNA-based therapies to previously unreachable cellular destinations across Amgen’s therapeutic areas.

• Help identify and implement new technologies to accelerate discovery at the leading edge of targeted delivery
• Generate and bring to life new approaches for realizing how extrahepatic RNA therapeutics can be deployed
• Collaborate closely with disease area, computational biology, and therapeutic development teams to make actionable decisions as a technical and intellectual subject matter expert
• Present research findings to cross-functional groups at internal and external meetings and publish scientific findings in peer-reviewed forums

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is an enthusiastic scientist with these qualifications.

• Doctorate degree PhD OR PharmD
• Or Master’s degree and 2 years of relevant scientific experience
• Or Bachelor’s degree and 4 years of relevant scientific experience

• PhD or Master’s in molecular biology, cell biology, RNA biology or a related discipline, with relevant industry or equivalent research experience in oligonucleotide therapeutics and/or genetic medicines.
• Experience performing high-throughput cell-based screening and generating sequencing‑based screening data using methods such as Drug‑seq, including sample preparation and quality control.
• Experience designing and executing studies of extrahepatic siRNA delivery using antibody‑siRNA conjugates and other delivery modalities, including in vivo study design, execution, sample processing and data interpretation.
• Demonstrated track record of independent critical thinking, complex problem solving, and innovative research, evidenced by significant scientific contributions.
• Ability to serve as a subject matter expert and representative on cross‑functional project teams: communicate data and recommendations clearly, coordinate with one or more therapeutic areas, and translate project questions into experimental plans including

From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and…