Senior Director of Quantitative Pharmacology Modeling & Simulation

Career Category Research Job  Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Director of Quantitative Pharmacology Modeling & Simulation What you will doLet’s do this. Let’s change the world. This position in Quantitative Pharmacology Modeling & Simulation will lead the strategy, development, and application of quantitative modeling and simulation capabilities that inform early drug-development decisions through prediction of human pharmacokinetics and pharmacodynamics. This senior leader will build and scale a high-performing team that integrates quantitative data to reduce uncertainty and improve confidence in candidate selection and human-dose projections.

The role combines deep scientific and technical expertise with strong organizational leadership. This role will be partnered closely with Precision Medicine, Toxicology, Operations, and the Clinical Pharmacology organizations to ensure a seamless transition from preclinical modeling to clinical development.

Key Responsibilities Define and execute the strategy, roadmap, investment priorities, governance, and operating model for model-informed drug design  Lead, develop, and retain a team with expertise in mechanistic and empirical modeling, PBPK, PK/PD, and quantitative systems of pharmacology to inform human-dose prediction. Establish a consistent modeling framework for investigational new drug–enabling activities Lead quantitative assessment of candidate differentiation, projected human exposure, dose and regimen feasibility, therapeutic index, and first-in-human starting-dose recommendations.

Drive development and application of PBPK, allometric scaling, mechanistic PK/PD, QSP, and related approaches appropriate to the asset, therapeutic area, and available evidence. Collaborate across Research and Development to ensure models reflect high-quality, fit-for-purpose data and relevant product attributes. Establish model-development, qualification, validation, documentation, reproducibility, and lifecycle-management standards. Participate in integrated program teams as a subject matter of expertise to clearly communicating quantitative evidence, uncertainty, assumptions, tradeoffs, and recommended actions.

Build external partnerships with academic institutions, technology providers, and scientific thought leaders to advance modeling capabilities. Manage the function’s budget, workforce plan, external vendors, and technology investments. What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications:

Doctorate degree in Pharmaceutical…