Scientist - LC-MS Bioanalytical

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Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas—Oncology, Inflammation, General Medicine, and Rare Disease—we reach millions of patients each year.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award‑winning culture is collaborative, innovative, and science based.

In this vital role, you will support the design, development, validation, and implementation of robust LC‑MS/MS bioanalytical methods for a wide range of therapeutic modalities—including small molecules, oligonucleotides, proteins, and other complex molecular entities—to enable GLP preclinical and regulated clinical studies. The position is lab‑based, with a significant emphasis on data management/fidelity, report generation, effective time management, communication, and data presentation.

• Perform quantitative bioanalytical experiments and organize data and results, including planning and running LC‑MS/MS bioanalysis and preparing and analyzing biological samples
• Develop and implement LC‑MS/MS bioanalytical methods with quick turnaround times
• Conduct small and large molecule bioanalysis in non‑clinical and clinical samples from various matrices (plasma, urine, CSF, tissues)
• Perform biological sample extraction using protein crash (PPT), SPE, LLE, and/or affinity capture methodologies
• Generate complete, accurate, and concise documentation using electronic systems and laboratory notebook
• Ensure bioanalytical data meets regulatory expectations for global submissions by maintaining accurate records and staying current with industry guidelines
• Author study reports, standard operating procedures, analytical methods, memos, and other regulatory‑compliant documents
• Communicate bioanalytical data to key discovery and development teams, contribute to scientific publications, and present at professional meetings
• Comply with safety guidelines and site‑specific procedures, including training completion, record maintenance, laboratory documentation, and SOP adherence
• Perform general laboratory housekeeping activities and operational support as needed, including QC of reports

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a dedicated scientist with the following qualifications.

• Doctorate degree (PhD, Pharm
  
  D, or MD) with relevant post‑doc where applicable and 1–3 years of relevant industrial or postdoctoral experience
• Or Master’s degree and 5 years of relevant industrial/technical experience
• Or Bachelor’s degree and 7 years of relevant industrial/technical experience

• Prior experience in CRO or pharma/biotech strongly desired
• Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms as well as HRMS
• Experience with an array of analytical technologies that can accelerate bioanalysis inclusive of automation and/or micro‑sampling
• Prior GLP and GCP experience
• Demonstrated expertise in working with a variety of sample types (e.g., blood, plasma, serum, tissues, cerebrospinal fluid) and employing diverse sample preparation techniques (e.g., SPE, LLE, immunocapture) to support analysis of different therapeutic modalities, including small and large molecules by LC‑MS
• Prior experience in bioanalytical (regulated) assay execution and transfer to CROs
• Must be willing to work in a fast‑paced, multi‑project environment with high workload demands, and consistently deliver high‑quality results within established timelines
• Demonstrated ability to resolve scientific challenges efficiently and prioritize effectively
• Excellent scientific…