Senior Research Associate – Single B Cell Screening & Functional Antibody Discovery

Kiso Ji Biotech is advancing next-generation antibody therapeutics through the integration of proprietary transgenic heavy chain-only antibody (HCAb) platforms, AI-guided discovery, functional screening technologies, and high-throughput single-cell screening systems.

We are currently expanding our antibody discovery capabilities and are seeking two Senior Research Associates to lead and support our single B cell screening and functional antibody discovery workflows using advanced technologies including the Cell Celector platform and potentially droplet microfluidics-based screening systems.

This is a highly hands-on laboratory role focused on screening plasma B cells following immunization campaigns to identify antibodies with desirable binding and/or functional activity. The position will involve close collaboration with multidisciplinary teams spanning molecular biology, protein engineering, AI-guided discovery, and functional assay development.

The successful candidates will thrive in a fast-paced biotech environment, demonstrate strong experimental rigor, work independently, and contribute scientifically to the development of next-generation antibody discovery technologies.

Senior Research Associate

Assay Development

• Plan and execute single B cell and plasma cell screening workflows following animal immunization campaigns
• Operate and optimize the Cell Celector platform for single-cell isolation, imaging, clone recovery, and antibody discovery applications
• Develop and execute screening assays for:
• Cell-based functional activity
• Support the implementation and optimization of droplet microfluidics-based screening technologies for high-throughput functional antibody discovery
• Perform mammalian cell culture and support functional screening workflows using reporter assays, flow cytometry, imaging systems, and cell-based assays
• Troubleshoot methods, improve workflows, and contribute to the development of new antibody discovery technologies
• Maintain accurate experimental records and clearly communicate results through reports, presentations, and team discussions
• Assist in SOP development, workflow standardization, and laboratory organization
• Collaborate closely with multidisciplinary teams across discovery, assay development, computational biology, and protein engineering
• Participate in project planning, prioritization, and technology evaluation discussions

• M.Sc. in Immunology, Cell Biology, Molecular Biology, Biotechnology, Bioengineering, or a related field with at least 5–7 years of industry experience
• Minimum 3 years of hands-on experience in antibody discovery or single-cell screening workflows
• Experience with mammalian cell culture and cell-based functional assays
• Experience operating advanced screening or cell handling instrumentation such as:
• Cell Celector
• FACS / flow cytometry systems
• Experience with one or more of the following:
• Single B cell screening
• Functional antibody screening
• Reporter-based functional assays
• Strong troubleshooting and problem-solving skills with the ability to independently optimize assays and workflows
• Excellent organizational skills and attention to detail
• Ability to work independently while effectively collaborating within cross-functional teams
• Strong verbal and written communication skills
• Legally authorized to work in Canada

• Experience with droplet microfluidics systems for single-cell or functional screening
• Experience with flow cytometry assay development and cell sorting
• Experience with reporter assays, imaging-based screening, or phenotypic screening
• Familiarity with automation and high-throughput screening systems
• Experience in oncology or GPCR-focused therapeutic discovery programs

Benefits Package Includes

• Health and Dental Insurance Plans
• Paid Vacation and Holidays

Incentive Programs Include

• Training & Development Programs / Courses
• Annual Performance Reviews with Yearly Bonuses
• Opportunity to work with cutting-edge antibody discovery technologies
• Exposure to advanced AI-guided therapeutic discovery platforms

The salary range for this position is $80,000–120,000 CAD, depending on experience, technical expertise, and qualifications. Compensation will take into account internal equity, work location, and relevant industry experience.

Kiso Ji Biotech is a collaborative and science-driven organization where innovation, teamwork, and scientific rigor are highly valued. Together, we believe we can help shape the future of antibody therapeutics and contribute meaningfully to the development of transformative medicines.