Principal Investigator - Reproduction, Pregnancy and Developmental Biology

The Lunenfeld-Tanenbaum Research Institute (LTRI) of Sinai Health, a University of Toronto-affiliated research centre, is seeking emerging leaders in the broad area of reproduction, pregnancy and developmental biology. Appointments will be for Full-Time Principal Investigator(s), rank equivalent to Assistant or Associate Professor, with a cross-appointment at the University of Toronto in the academic department best aligned with the candidate’s background and research topic, with the anticipated starting date of September 1, 2027, or a date to be mutually agreed upon.

The LTRI provides competitive start-up packages and salaries, commensurate with experience and qualifications.

We are seeking new colleagues who will develop innovative, outstanding and independent research programs in one of the following topic areas:

(i) Maternal-Fetal Health:
Examples of topics of interest include the investigation of fundamental biological processes underlying placentation and maternal-fetal adaptations; disease modeling and the pathophysiology of pregnancy-associated complications (e.g., preeclampsia, preterm birth, gestational diabetes); therapeutic discovery; and the developmental origins of health and disease.

(ii) Reproductive and Developmental Biology:
Examples of topics of interest include reproductive biology, early embryogenesis, lineage specification, morphogenesis, and the developmental origins of health and disease. We welcome applications exploring the molecular, cellular, and genetic mechanisms that drive early development and stem cell dynamics.

Research approaches and methodologies across both areas of interest may include, but are not limited to: hypothesis-driven mechanistic studies; the generation and analysis of large-scale multi-omic datasets (including single-cell genomics and spatial transcriptomics); advanced live-cell or super-resolution imaging; computational modeling of developmental trajectories; and the engineering of advanced in vitro models (such as stem cell-based embryo models, organoids, or micro-physiological systems) or in vivo models.

The Lunenfeld-Tanenbaum Research Institute is one of Canada’s leading biomedical research institutes, located within Mount Sinai Hospital at Sinai Health in downtown Toronto. LTRI’s faculty members are internationally renowned for their focus on improving human health, driven by a legacy of foundational discoveries in maternal and infant health, developmental and cellular biology, genetic disorders, and stem cell biology, with strengths in cancer, inflammatory conditions and other areas of human disease.

The Lunenfeld-Tanenbaum Research Institute is committed to excellence in biomedical research, the development of early career investigators, and the training of the next generation of researchers. A dedicated Research Trainee Centre supports trainees across disciplines from around the world.

The Institute provides a research-intensive environment with innovative core facilities spanning proteomics, single-cell and spatial genomics, laboratory automation and advanced cellular imaging, supporting both technology development and cutting-edge biological research. These facilities include the Network Biology Collaborative Centre and the Nikon Centre of Excellence. LTRI is also home to The Centre for Phenogenomics, a state-of-the-art facility for mouse models, and is a founding member of the Nanoscale Biomedical Imaging Facility.

LTRI benefits from close ties with flagship clinical programs focusing on fetal medicine and women’s health, cancer and cancer genetics, diabetes, autoimmune/inflammatory diseases, complex medicine, complex orthopedics, geriatrics and infectious disease. Together with a strong history of…