Postdoctoral Research Associate, Cellular and Molecular Medicine

Postdoctoral Research Associate, Cellular and Molecular Medicine

Posting Number req
27032

Department Cellular & Molecular Medicine

Department Website Link https://cmm.arizona.edu/

Location Tucson Campus

Address 1501 N. Campbell Ave., Tucson, AZ 85719 USA

The Romanoski Laboratory at the University of Arizona invites applications for a Postdoctoral Research Associate in vascular genomics and systems genetics. Our research program uses integrative genomics approaches to define the molecular mechanisms by which genetic variation shapes endothelial cell biology and confers risk for coronary artery disease (CAD) and microvascular dysfunction. The successful candidate will join a collaborative, scientifically rigorous environment at the intersection of vascular cell biology, chromatin biology, and human genetics.

This position offers hands-on training in state-of-the-art experimental and computational methods, including single-cell genomics, chromatin profiling, quantitative trait locus (QTL) mapping, and integration with large-scale biobank resources. The postdoc will contribute to active NIH-funded projects focused on shear stress-responsive RNAs and endothelial genetic mediators of microvascular dysfunction, with opportunities to develop independent research directions.

• Visa sponsorship is not available for this position.

Outstanding U of A benefits include health, dental, vision, and life insurance; paid vacation, sick leave, and holidays; UA/ASU/NAU tuition reduction for the employee and qualified family members; access to UA recreation and cultural activities; and more!

The University of Arizona has been recognized for our innovative work‑life programs. For more information about working at the University of Arizona and relocation services, please .

The laboratory combines human endothelial cell culture and perturbation systems with genomic discovery tools to dissect how genetic variation at CAD-associated loci operates through the vessel wall.

• Quantitative Trait Locus (QTL) mapping in human endothelial cell cohorts exposed to variousin vitro environments.
• Genetic and heterogeneity-based analysis of endothelial cell molecular traits using single-cell RNA sequencing and chromatin accessibility profiling.
• Colocalization and Mendelian Randomization between genetic signals in endothelial cells and GWAS signals for vascular phenotypes.
• Integration with population-scale biobanks including UK Biobank, All of Us, and others.
• Functional characterization of candidate effector genes using laboratory assays for endothelial functions.

• Design and execute experiments using primary human endothelial cells.
• Prepare and QC sequencing libraries including bulk RNA‑seq, small RNA‑seq, ATAC‑seq, and single-cell libraries.
• Perform genome-scale mapping and genetic colocalization with GWAS summary statistics.
• Analyze *-seq datasets using standard and custom bioinformatics pipelines.
• Contribute to grant writing, manuscript preparation, and presentations at national conferences.
• Mentor and support trainees and other members of the laboratory.

• Ability operating specialized equipment in a laboratory setting.
• Proficiency in sequencing library preparation, including bulk RNA‑seq, small RNA‑seq,ATAC‑seq, and single‑cell sequencing protocols.
• Knowledge of genetic colocalization methods using GWAS and molecular QTL summary statistics.
• Working knowledge of large-scale biobank resources, particularly the All of US Research
  
  Program and phenome‑wide association study (PheWAS) frameworks.
• Biological knowledge of vascular cell types, endothelial function, and the pathobiology of atherosclerosis.

• Doctoraldegr…