Research Laboratory Technician

Biomedical & Life Sciences
Location: Bailrigg, Lancaster, UK
Salary: £26,707 to £30,378 (Full time, indefinite with end date)
Closing Date: Sunday 09 August 2026
Interview Date: Wednesday 26 August 2026
Reference: 0607-26

This role involves supporting studies in DNA replication stress response signalling, including:

• Generate and characterise engineered cell lines with inducible gene expression, gene depletion, and targeted genetic modifications, including domain deletions and site‑directed mutations.
• Investigate cellular responses to DNA damage and replication stress using a range of molecular and cell biology approaches, including immunofluorescence microscopy, immunoblotting, DNA fibre assays, and micronucleus analysis.
• Examine protein localisation and chromatin‑associated dynamics at sites of DNA replication and genome maintenance using advanced imaging and proteomic techniques.
• Characterise protein–protein and protein–nucleic acid interactions through biochemical and proximity‑based assays, including immunoprecipitation and proximity ligation assays.
• Identify and analyse interaction networks and candidate substrates of a target pathway regulator using mass spectrometry‑based proteomics.

As part of a friendly and collaborative team, you will be responsible for:

• Preparing and conducting experiments including engineered cell line generation, DNA damage response analysis, protein interaction and localisation studies, and proteomic identification of molecular interaction networks.
• Data acquisition and management, and contributing to analysis and reporting.
• Supporting day‑to‑day lab operations, including equipment maintenance, ordering supplies, record keeping, and assisting with regulatory documentation.
• Providing technical training to students and other lab members.

We are keen to hear from candidates who have:

• Bachelor’s degree in biomedicine, biomedical sciences, biochemistry or a related discipline.
• Experience supporting biomedical studies, including mammalian cell culture, immunoblotting, immunofluorescence, DNA cloning, molecular biology techniques and data analysis using Graph Pad‑Prism and Image
  
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• Strong organisational and administrative skills, including inventory management, accurate record keeping, and report writing.
• A proactive approach to problem‑solving and technical troubleshooting, with the confidence to take initiative and work independently.
• Excellent written and verbal communication skills, and a collaborative, team‑oriented approach.

Experience with the DNA fibre assay is desirable but not essential. Training will be provided for the right candidate. Most importantly, you will bring motivation, attention to detail, and enthusiasm for contributing to meaningful interdisciplinary research.

You will join the Genome Stability and DNA Repair Lab, led by Dr. Panagiotis Kotsantis in the Division of Biomedical and Life Sciences, and work in an interdisciplinary team with collaborators from BLS and Erasmus University (Netherlands). This role therefore offers a fantastic opportunity to gain hands‑on experience across diverse research methods and environments.

The Division of Biomedical and Life Sciences, part of the Faculty of Health and Medicine, is a vibrant and interdisciplinary research environment focused on human health and disease. It offers state‑of‑the‑art facilities and a collaborative, inclusive culture that supports both independent and team‑based research, while promoting work‑life balance and individual support.

The Faculty has held a Silver Athena SWAN award since 2014 in recognition of its good employment practice undertaken to address gender equality in higher education and research.

The University recognises and celebrates good employment practice undertaken to address all inequality in higher education while promoting wellbeing for all its colleagues.

We warmly welcome applicants from all sections of the community regardless of age, religion, gender identity or expression, race, disability or sexual orientation, and are committed to promoting diversity and equality of opportunity.