Principal Scientist - Toxicology

Overview  Each of us cares about someone who will need medicines. That’s why our vision is to repeatedly beat the odds to deliver breakthrough medicines to patients that need them. We pursue truth and scientific rigour and have the courage to work at the edge of the unknown.
We are looking for an experienced, strategically minded Principal Scientist to join our expanding Non-Clinical Safety team based in Vancouver, Canada. You will be responsible for designing, planning, monitoring, and reporting of non-GLP and GLP toxicology studies and provide nonclinical safety support for early to late stage programs.
How you might spend your days
Leading the planning, design, execution and and interpretation of nonclinical toxicology programs in support of IND, CTA and BLA submissions, including general toxicity and reproductive and developmental toxicology studies, in alignment with global regulatory expectations and program strategy
Serving as the primary scientific interface with contract research organizations (CROs), providing strategic oversight during protocol development, study conduct, data interpretation, and report finalization to ensure timely, high-quality, and GLP-compliant delivery of nonclinical studies
Representing the Nonclinical Safety function as a core member of cross-functional discovery and development program teams, contributing toxicology expertise to inform candidate selection, risk assessment, and overall program advancement
Providing critical scientific assessment of toxicology data and communicating clear, actionable risk-benefit evaluations and recommendations to project teams and senior leadership, including potential implications for clinical development and regulatory strategy
Authoring and reviewing nonclinical safety sections of regulatory documents (INDs, CTAs, IBs, and BLAs), and contributing as a subject matter expert to global regulatory interactions and health authority responses
Driving the development and evolution of integrated nonclinical safety strategies across AbCellera’s therapeutic portfolio, ensuring consistency, scientific rigor, and alignment with company objectives
Maintaining scientific leadership by staying current with advances in toxicology science, methodologies, and evolving regulatory guidance, and proactively translating these insights into best practices for internal programs
We d love to hear from you if
You bring deep expertise in GLP-compliant nonclinical toxicology, including hands-on experience with US FDA 21 CFR Part 58, and a strong working knowledge of FDA, ICH, and EMA nonclinical regulatory guidance
You have a proven track record of designing, overseeing, and interpreting non-GLP and GLP toxicology studies in support of discovery and development programs; experience with oncology and/or ADC programs is highly desirable
You hold a PhD in Toxicology or a related field, with 8+ years of relevant industry experience supporting biologics development; candidates with a MSc degree and 12+ years of directly applicable experience will also be considered
You demonstrate the ability to lead scientific discussions and influence decision-making within highly matrixed, cross-functional teams through clear, confident, and effective communication
You possess excellent scientific writing skills, with experience authoring and reviewing toxicology reports and regulatory submission documents
You exhibit strong organizational and prioritization skills, enabling effective management of multiple programs and timelines in a fast-paced environment
You apply sound scientific judgment and critical problem-solving skills to assess complex datasets, identify risks, and propose strategic solutions
You thrive in a dynamic, evolving environment, demonstrating flexibility, resilience, and a proactive approach to change
You hold DABT accreditation (highly desirable, but not required)
What we offer
AbCellera’s hiring range for this role is CAD $134,000 - $168,000 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP…