Principal Scientist - In Vivo Pharmacology

Overview

AbCellera’s platform integrates biology, computation, and engineering to develop impactful antibody‑based medicines. We’re scientists, engineers, and business professionals who work together to turn scientific insights into breakthrough medicines. We pursue truth and scientific rigor. We think independently, act with conviction, and have the courage to work at the edge of the unknown. We offer the opportunity to stretch and explore, and to work on things that matter.

• Lead internal preclinical in vivo pharmacology studies to support programs around different disease indications.
• Design, support execution, and interpret in vivo pharmacology studies to generate proof‑of‑concept data and build confidence in the selection of molecules for clinical development.
• Evaluate available data sets to identify animal models, build testable biological hypotheses for new targets, and preclinically assess those hypotheses.
• Work closely with internal teams and/or external CROs to execute in‑vivo preclinical studies efficiently and effectively.
• Collaborate with cross‑functional project teams within protein engineering, in vitro biology, pharmacokinetics, modeling, and biomarkers to identify lead molecules and advance programs to human clinical trials.
• Support and mentor in vivo pharmacology teammates by providing scientific expertise and practical support during preclinical study design, execution, and data analysis.
• Collaborate with the project team and teammates on regulatory documents to support regulatory filing.
• Report findings to program teams and senior leadership to support data‑driven decisions.

• A strong background in preclinical drug development of biologics in an industry setting, including discovery, identification and establishment of animal models, in vivo pharmacology, and efficacy in disease models.
• Experience in oncology, immunology, or pain (desirable); scientific expertise in other disease areas also considered.
• A Ph.D. in pharmacology, immunology, or a related field, plus at least 8 years of experience in a biopharmaceutical industry setting; candidates with a MSc and 12+ years of relevant industry experience also considered.
• Proven interpersonal skills and the ability to create value on cross‑functional teams.
• Genuinely curious, with an interest in discussing innovative ideas in a highly cooperative and fast‑paced environment.
• A good ability to communicate scientific and/or technical concepts with an emphasis on application.
• Ability to independently identify project needs and construct and implement solutions.
• Enjoy teamwork that comes with working on complicated biological questions and building data sets that help predict the success of therapies.

AbCellera’s hiring range for this role is CAD $135,000-$168,600 annually, commensurate with your education and job‑related knowledge, skills, and experience. In addition to base salary, we offer equity, an annual bonus dependent on team and company performance, and a 6% non match RRSP contribution. You will receive a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, professional development opportunities, and comprehensive health benefits.

AbCellera is a global company focused on delivering breakthrough medicines that alleviate suffering, extend lives, and improve health. Our platform includes fully integrated capabilities to create first‑in‑class and best‑in‑class antibody medicines, from discovery to clinical manufacturing. We are advancing programs involving complex transmembrane proteins, bispecifics, and antibody drug conjugates. Creating medicines is the most important work we can do.