Process Development Scientist

Polymorphic Biosciences is a privately funded research incubator based in Vancouver, BC that explores novel applications of lipid nanoparticle technology. Our projects range from early-stage exploratory research to applied development for commercial applications.

Position Overview
As a  Process Development Scientist , you will be responsible for generating the experimental data that drives our LNP manufacturing platform. This is a bench-heavy, independent role requiring hands‑on expertise in lipid nanoparticle formulation and tangential flow filtration. We are a small team building something new, and we need someone who brings both rigour and adaptability to the role.

Key Responsibilities

Serve as the technical lead for LNP formulation and TFF process development, owning the experimental program from study design through to data analysis and reporting

Establish and maintain the analytical characterization workflow for LNP quality attributes (particle size, PDI, encapsulation efficiency, yield)

Build the process knowledge base — defining critical process parameters, operating ranges, and reproducibility boundaries

Develop documentation and workflows to a standard that supports future scale-up and technology transfer into a cGMP environment

Communicate findings clearly to both internal stakeholders and external partners through presentations, technical reports, and informal updates

Contribute to the broader R&D program as priorities evolve

Knowledge and Qualifications
Required

MSc or PhD in chemical engineering, pharmaceutical sciences, bioengineering, or a related field, with 3+ years of relevant industry experience

Hands‑on experience in LNP formulation and tangential flow filtration

Advanced technical knowledge in process development and Quality by Design (QbD) principles

Strong experimental design skills with a systematic approach to process characterization

Familiarity with cGMP concepts and regulatory considerations in the biotech/pharmaceutical industry

Excellent written and verbal communication skills, with the ability to present technical findings to diverse audiences

Strong critical thinking, attention to detail, and the ability to work independently in a developing environment

Preferred

Direct experience working in or supporting a cGMP manufacturing environment

Familiarity with RNA-based therapeutics (mRNA, siRNA)

What We Offer

Salary range: $70k - $100k per annum

Comprehensive medical and dental coverage after 3 months

Opportunities for professional growth and development

Collaborative and innovative research environment

Contribution to cutting‑edge therapeutic development

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