Research Associate in Cardiothoracic Transplantation and Multi-Omics Biomarker Research

A Research Associate (RA) position is available at the University of British Columbia (UBC), Division of Respiratory Medicine, Department of Medicine under the direction of Dr. Scott J. Tebbutt, Professor of Medicine of UBC Faculty of Medicine and Principal Investigator at the Centre for Heart Lung Innovation at St Paul's Hospital.

We are seeking a highly motivated and experienced Research Scientist with a strong background in cardiothoracic transplantation, biomarker discovery, and multi-omics research to join our multidisciplinary research team. The successful candidate will lead pioneering projects aimed at improving diagnostic accuracy, predicting transplant outcomes, and addressing the complexities of post-COVID-19 condition (long COVID). This role offers an exciting opportunity to work at the forefront of cardiothoracic transplantation, precision medicine, and public health research.

The RA will work with an interdisciplinary and international team to support ongoing and new transplant-related biomarker studies, including heart transplantation and lung transplantation. The RA and Dr. Tebbutt's team members aim to discover and validate plasma metabolomic and proteomic biomarkers, integrate multi-omics data, and develop predictive models to improve early detection and clinical management of allograft dysfunction. While the primary focus will be on cardiothoracic transplant biomarker studies, the RA will also contribute to ongoing COVID-19/long COVID research led by the team.

The RA will play a pivotal role within the project team, providing scientific expertise in cardiothoracic transplantation and COVID-19 research. They will be responsible for supporting hypothesis generation, planning, coordination, and the identification of host molecular endotypes associated with diverse COVID-19 outcomes and new viral variants in a longitudinal multi-omics cohort study of 1,000 patients with COVID-19. For the cardiothoracic transplantation research work, the RA will test newly developed blood biomarkers using patient samples from four major heart transplant centers and one lung transplant center.

• Lead and execute research projects focused on developing non-invasive biomarkers for diagnosing and predicting outcomes in cardiothoracic transplantation
• Conduct multi-omics research (metabolomics, proteomics, genomics) to identify metabolic signatures and pathways associated with transplant rejection and post-transplant outcomes
• Investigate the pathogenesis and biomarkers of long COVID, contributing to therapeutic strategies that address SARS-CoV-2 persistence, immune dysregulation, chronic inflammation, vascular injury, hypercoagulability, and multi-organ involvement
• Collaborate with clinicians, bioinformaticians, and public health researchers to apply precision medicine approaches, including the development of real-time diagnostic tools for clinical use
• Coordinate and develop grant applications to secure research funding
• Prepare manuscripts and scientific reports for the dissemination of research findings and publish high-impact research articles in peer-reviewed journals and present findings at international conferences
• Mentor junior researchers, postdoctoral fellows, and graduate students, fostering a collaborative and innovative research environment
• Analyze experimental data and perform statistical analyses, including omics, to drive research insights
• Stay updated on emerging COVID-19 interventions and models of care, especially in the respiratory domain
• Conduct literature reviews and systematic reviews relevant to research goals
• Facilitate the development of research registries, including scope and strategy formulation
• Prepare and deliver presentations for research…