Associate Manufacturing Scientist II; 3rd Shift

Associate Manufacturing Scientist II (3rd Shift)

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein.

Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics.

Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

The Position

The Associate Manufacturing Scientist II (third shift) will involve assisting in the synthesis and subsequent purification steps of large scale oligonucleotides. The operator must comply with GLP/GMP protocols and be able to follow all association SOPs and work instructions when performing and documenting operations.

3rd shift work hours are 10 pm – 8:30 am and includes a 15% shift differential.

Responsibilities

• Follow batch records, SOPs, and work instructions to detail
• Document all operations in batch records and notebooks
• Comply with GMP protocols
• Assist other chemists within the CMC group during synthesis and chromatography of oligonucleotides including
  • Reagent solution preparation
  • Column Packing
  • Mobile phase preparation
  • Fraction collection
• Operate a lyophilizer and package solid drug substance
• Execute processes as part of a team to ensure production timelines are kept and quality product is produced
• Maintain a clean work space
• Maintain safety by wearing required personal protective equipment

Requirements

• BS or MS in chemistry, biochemistry, engineering, or related scientific field
• Entry level to 3 years experience in a similar position
• Good verbal and written communication skills
• Ability to work in a team environment
• Ability to pay attention to detail

Preferred

• Experience working in a GMP setting with controlled documentation

All applicants must have authorization to work in the US for a company.

Arrowhead provides competitive salaries and an excellent benefit package.

Location:

Verona, WI | Salary: $63,000.00-$73,000.00