Senior Director, Commercial Forecasting & Artificial Intelligence

Join Immatics and shape the future of cancer immunotherapy; one patient at a time! Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting‑edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T‑cell therapies and TCR bispecifics.

• Innovative Environment:
  Help to pioneer advancements in cancer immunotherapy.
• Collaborative Culture:
  Be part of a diverse team dedicated to your professional growth.
• Global Impact:
  Contribute to therapies that make a lasting impact on patients globally.

We are seeking a Senior Director, Commercial Forecasting & AI combined role. Approximately half of the position is owning demand, revenue and patient‑flow forecasting across Immatics’ portfolio — from early pipeline opportunity assessment through launch readiness and in‑line performance. The other half is serving as the Commercial organization’s in‑house AI expert: identifying, building and scaling AI and generative‑AI capabilities that make a small commercial team perform like a much larger one.

The successful candidate is a recognized forecasting expert in oncology or cell and gene therapy who has already put AI to practical, compliant use in a life sciences commercial setting.

Reports to:

VP Commercial Analytics & Operations

Location:

Remote U.S.

Salary Range: $240,000 – $280,000

• Bachelor’s or equivalent years of experience 15+ years in Life sciences consultancy, biotech, pharma or related

• 7 Years of Forecasting, Commercial Analytics or market insights
• Demonstrated expertise building patient‑based and epidemiology‑driven forecast models from the ground up for both pre‑launch and in‑line assets.
• Deep working knowledge of pharma/biotech data sources and their strengths and limitations — e.g. IQVIA, Symphony Health, Komodo, Definitive Healthcare, specialty distributor and 867/852 data, SEER and other epidemiology sources, clinical registries and syndicated market research.
• Demonstrated, hands‑on experience applying AI and large language models to real commercial problems in a regulated life sciences environment — including practical fluency with LLM platforms, prompt engineering, retrieval‑augmented generation and agentic workflows, and a clear‑eyed view of where AI does and does not work.
• Working understanding of the compliance and privacy constraints on AI in life sciences (PHI/HIPAA, GDPR, promotional review, data licensing terms, emerging AI regulation).
• Advanced Excel modeling plus working proficiency in Python, SQL and a visualization tool (Power BI/Tableau).
• Experience across the launch lifecycle in oncology, cell and gene therapy, rare disease or another specialty/limited‑distribution setting.
• Proven ability to operate independently in a lean, fast‑moving environment, and to translate complex quantitative and technical work into decision‑ready recommendations for senior stakeholders.
• Direct experience forecasting an autologous CAR‑T, TCR‑T or other engineered cell therapy asset, including site activation and manufacturing‑constrained demand models.
• Track record of standing up a forecasting or commercial AI capability at a pre‑commercial or newly commercial company.
• Exposure to global forecasting and to market access/pricing analytics in specialty oncology.

• Develop Commercial AI roadmap — Serve as the Commercial team’s resident AI expert across the full commercial organization: partner with Marketing, Market Access, Medical Affairs and Field Operations to identify, prioritize and sequence high‑value AI…