Director, Cost Accounting

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at  , and follow us on X , Linked In and Facebook .

Role

Summary:

The Director, Inventory / Cost Accounting leads Dyne’s inventory and cost accounting strategy and established the financial infrastructure required to support commercial launch and continued portfolio growth. This role owns the development, implementation and governance of cost accounting processes, inventory valuation, and related controls across clinical and commercial products manufactured through third-party CMOs and CDMOs.. The Director serves as the company’s subject matter expert for inventory and cost accounting, providing strategic guidance on product costs, capitalization, reserves, gross margin, and complex accounting judgments.

This highly visible role influences business decisions by translating manufacturing and supply chain activity into clear financial insights and recommendations for senior leadership.

The Director partners closely with Supply Chain, Technical Operations, Commercial Operations, FP&A, external manufacturing partners, and auditors to ensure accurate, scalable, and audit-ready processes. This role sets priorities, directs cross-functional initiatives, and develops the capabilities and resources needed to support Dyne’s transition from clinical development to a multi-product commercial organization.

This is a full-time position based in Waltham, MA without the possibility of being remote.

Primary

Responsibilities Include:

Cost Accounting & Costing Methodology

• Develop, implement, and maintain cost models for commercial product(s) manufactured through third-party CMOs/CDMOs
• Establish and maintain bill of materials (BOM) and routing cost structures in collaboration with Supply Chain and Technical Operations
• Perform periodic cost updates and manufacturing/production variance analysis
• Analyze and report on cost of goods sold (COGS)

Inventory Accounting

• Own inventory accounting for raw materials, work-in-process, clinical supply, and finished goods held at third-party locations
• Direct the period-end inventory and accounting close, ensuring accurate reporting, appropriate review, and timely resolution of issues
• Manage inventory reserve methodology and perform periodic assessments
• Manage physical inventory counts and cycle count programs across CMOs,CDMOs, and third-party logistics (3PL) providers
• Determine and document appropriate accounting treatment for inventory used across clinical and commercial operations

CMO/CDMO Cost Management

• Serve as the finance leader for cost-related aspects of CMO/CDMO relationships, including invoice review, cost true-ups, and technical transfer cost accounting
• Partner with Supply Chain, Technical Operations, Commercial Operations, and FP&A to incorporate cost insights into operating plans, forecasts, launch decisions, and gross margin strategy.
• Support cost impact analysis for manufacturing process changes, scale-up activities, and technology transfers
• Establish and maintain a scalable control environment for inventory and cost accounting that complies with U.S. GAAP, SOX requirements, and public company standards
• Prepare monthly, quarterly, and annual cost accounting analyses and…