Director, Government Pricing & Operations

Waltham, MA

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at  , and follow us on X , Linked In and Facebook .

Role

Summary:

The Director, Government Pricing & Contract Operations is a key leader within U.S. Pricing & Contracting responsible for ensuring the compliant execution, oversight, and continuous improvement of government pricing and contract administration processes. This role serves as the internal subject matter expert for government pricing regulations, methodologies, and reporting requirements while overseeing external vendors responsible for calculation, validation, submission, and operational support activities.

The Director will partner closely with Market Access, Finance, Legal, Compliance, Trade, and Commercial Operations to evaluate the impact of pricing and contracting strategies on government price reporting and contractual obligations. This position is accountable for maintaining a robust compliance framework, ensuring operational excellence, and driving effective vendor governance across all government pricing and contract administration activities.

This role is based in Waltham, MA without the possibility of being fully remote.

Primary

Responsibilities Include:

Government Pricing & Reporting

• Serve as the internal expert on U.S. Government Pricing programs, including AMP, Best Price, ASP, Medicaid Drug Rebate Program, 340B, Non-FAMP, FCP, and Federal Supply Schedule pricing.
• Oversee third-party vendors responsible for government pricing calculations, validations, submissions, and reporting.
• Review and approve pricing methodologies, assumptions, and reporting outputs to ensure compliance and accuracy.
• Assess the impact of pricing, contracting, distribution, and market access strategies on government price reporting.
• Monitor and implement regulatory and policy changes, including CMS, OIG, and Inflation Reduction Act (IRA) requirements.
• Maintain government pricing policies, SOPs, controls, and documentation to support compliance and audit readiness.
• Lead responses to audits, compliance reviews, and governmental inquiries.
• Partner with Finance to support rebate accruals, forecasting, and financial reporting requirements.
• Drive process improvements, automation, and data quality initiatives to enhance operational efficiency and compliance.

Contract Operations & Administration

• Provide leadership and oversight for contract operational processes, ensuring accurate implementation and administration of approved contract terms.
• Ensure accurate maintenance of contract records, documentation, eligibility files, and contract management systems.
• Oversee rebate administration processes, including validation, adjudication, dispute resolution, and payment activities managed through external vendors.
• Partner with Legal, Market Access, and Compliance to evaluate contract structures, operational feasibility, and government pricing implications.
• Drive continuous improvement initiatives to enhance operational efficiency, reporting and analytics capabilities, and performance measurement to support informed business decision-making and contracting strategies.
• Maintain contract…