Sr. Manager, Clinical Finance BP

As the Senior Manager, Clinical Finance Business Partner
, you will report to the Director, Clinical Finance and serve as a key Finance Business Partner to Clinical Operations and the broader R&D organization. You will will own the financial management of the clinical study portfolio within assigned TAs, PSTs, assets, and/or studies, with primary responsibility for Clinical Operations external spend, including CROs, clinical vendors, FSP resources, and other study execution costs.

You will will provide end-to-end financial oversight across the clinical study lifecycle, from study planning and scenario development through execution, forecasting, governance, and close-out. You will partner closely with Clinical Operations, TA Finance, PSTs, Study Leads, GPLs, CPMs, and other R&D stakeholders to translate clinical and operational assumptions into financial insights and ensure study financials are appropriately reflected in broader asset and portfolio decisions.

Beyond core study financial management, upi will provide forward-looking analysis to support clinical development scenario planning, governance, Business Development due diligence, and continuous improvement across Clinical Finance and R&D Finance.

This is a hybrid role, requiring three (3) days of onsite work weekly. #LI-hybrid

Clinical Study Financial Management & Business Partnering

• Own the financial management of assigned clinical study portfolios, providing end-to-end financial oversight throughout the study lifecycle.
• Maintain a comprehensive and forward-looking view of study financials, including approved budgets, actuals, commitments, accruals, forecasts, POs, vendor contracts/SOW, and FSP costs.
• Lead PST and Asset level budgeting, forecasting, month-end closing, accrual and prepayment activities, variance analysis, and financial reporting.
• Monitor financial performance against approved budgets and forecasts, proactively identifying and communicating key risks, opportunities, potential gaps, and changes in financial outlook.
• Partner closely with TA Study Leads, GPLs, CPMs, and Clinical Operations to understand study execution and ensure forecasts reflect current assumptions, including timelines, enrollment, site activation, geographic mix, vendor activities, and contractual commitments.
• Collaborate with TA Finance to ensure clinical study financials, assumptions, risks, opportunities, and scenarios are appropriately incorporated into the broader asset and R&D financial outlook.
• Provide clear financial insights and recommendations to support study, portfolio, and business decisions.

Financial Modeling, Scenario Planning & Decision Support

• Develop, enhance, and maintain robust clinical financial models to support study costing, scenario planning, and decision-making, with transparent assumptions, key cost drivers, and sensitivities.
• Lead financial analysis of clinical development scenarios, including alternative study designs, patient populations, enrollment assumptions, timelines, geographic/site strategies, study sequencing, and other key development assumptions.
• Translate clinical and operational scenarios into clear financial implications, sensitivities, risks, opportunities, and investment requirements.
• Provide financial analysis, modeling, and business cases to support PRISM and other R&D governance and investment decisions.
• Partner with Clinical Operations, Clinical Development, TA Finance, PSTs, and other stakeholders to ensure financial scenarios appropriately reflect clinical and operational strategies.
• Clearly communicate complex assumptions and financial implications to Finance and non-Finance stakeholders.

CRO & Vendor Financial Management

• Conduct regular financial reviews with CROs and other clinical study vendors, covering actuals, accruals, commitments, forecasts, change orders, and overall budget status.
• Review and track study work orders and unit-based charges, challenging activity assumptions, unit volumes, rates, and variances against contract, budget, and forecast.
• Assess the financial impact of contract amendments, change orders, and evolving study requirements and ensure these are appropriately reflected in forecasts.
• Partner with R&D contracts & outsourcing team, ensuring alignment among contracts, work orders, POs, invoices, budgets, and forecasts.

Business Development & Due Diligence

• Provide Clinical Finance support for Business Development and due diligence activities, with a focus on clinical development plans and associated…