Manager, Supply Chain Planning

Manager, Supply Chain Planning at Dyne Therapeutics

Location: Waltham, MA

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at  and follow us on X, Linked In and Facebook.

The Manager, Supply Chain Planning is responsible for end‑to‑end inventory and production planning across Dyne’s external supply network. This includes long‑range planning (LRP), ensuring uninterrupted clinical supply, and supporting commercial launch readiness through scenario‑based planning and risk assessments. The role is critical in executing current planning activities and shaping future supply‑chain capabilities. The Manager collaborates cross‑functionally with internal stakeholders (e.g., the wider CMC team, Regulatory, Quality, Clinical Operations, and Commercial teams) as well as external partners and service providers.

This is a full‑time position based in Waltham, MA.

• Collaborate with cross‑functional partners in Technical Operations, Logistics, Quality, Clinical Operations, and Commercial to develop and maintain a reliable demand and supply plan, ensure supply continuity, uninterrupted clinical supply for patients, support commercial readiness, and align with the company’s business objectives.
• Maintain an understanding of external manufacturing site capacities, capabilities, and supply risks.
• Perform scenario planning to evaluate alternative demand and supply assumptions and inform risk mitigation strategies.
• Maintain vendor forecasts in alignment with clinical and commercial demand forecasts as well as contracted minimum production requirements.
• Balance production across supply network to maintain set inventory targets.
• Manage master data, demand forecasts, and accurate stock levels in SCmple Supply Chain Planning tool.
• Manage purchase orders and invoice reconciliation from external vendor network.
• Support the implementation of an Enterprise Resource Planning (ERP) system.

• Coordinate and oversee shipments of materials between CMOs, warehouses, 3PLs, Test Labs and other supply chain nodes.
• Support network re‑supply, working closely with internal stakeholders (Quality, Manufacturing) and external partners (couriers, CMOs, customs brokers, and warehouse providers).
• Ensure timely and compliant shipments, including documentation preparation, booking, tracking, and post‑shipment follow‑up, closure and archiving.
• Troubleshoot logistics issues and implement corrective actions as needed.

• Ensure all planning and logistics activities are conducted in compliance with GMP, GDP, and other applicable regulations.
• Author, implement and maintain the necessary Supply Chain‑related standard operating procedures (SOPs) and work instructions.
• Collaborate with Quality and Regulatory teams to ensure proper handling of clinical and commercial materials.
• Collaborate with cross‑functional teams to establish processes and capabilities to support ongoing clinical operations and future commercial operations.

• Bachelor’s degree in Life Sciences, or related field; advanced degree or certification is a plus.
• 5 years total experience, 3+ years in supply chain planning, preferably within the pharmaceutical or biotech industry.
• Ability to effectively plan, prioritize, execute, follow up and anticipate challenges.
• Experience managing complex schedules and priorities in dynamic pharmaceutical, biotech or related environments.
• Ability to work, influence, and gain agreement across multiple functions.
• Strong analytical, problem‑solving, and critical‑thinking skills.
• Experience…