Manager, HR Operations & Onboarding

Company Overview

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more , and follow us on X, Linked In and Facebook.

The Manager, HR Operations & Onboarding partners with the HR team to continuously enhance Dyne’s core HR operational functions, including onboarding, HRIS administration, benefits coordination, and process optimization. This role serves as a point of contact for employee HR‑related questions and provides timely, accurate guidance to employees and managers on policies, processes, and systems. The Manager leads and oversees the onboarding experience, ensuring new hires have a seamless and engaging transition into Dyne.

Additionally, this role maintains data integrity across Dyne’s HR systems (ADP Workforce Now and Greenhouse ATS) and drives automation to enable scalability, efficiency, and a best‑in‑class employee experience. This role is based in Waltham, MA.

• Support day‑to‑day HR operations, ensuring accuracy, efficiency, and compliance across onboarding, HRIS management, and benefits administration
• Oversee and optimize workflows within ADP Workforce Now and Greenhouse ATS, ensuring seamless data flow and system integration
• Design, manage, and continuously improve Dyne’s onboarding processes, systems, and programs to deliver an engaging and consistent new hire experience aligned with Dyne’s culture and values
• Serve as the first point of contact for general HR inquiries, providing timely and accurate support to employees and managers
• Ensure compliance with all employment‑related documentation and record‑keeping requirements
• Collaborate closely with Talent Acquisition, IT, and HR Business Partners to streamline processes and enhance service delivery
• Partner with external vendors to manage Service Level Agreements and ensure high‑quality service delivery
• Oversee contract lifecycle and purchase order management, including creation, tracking, and reconciliation, ensuring alignment with procurement policies and timely vendor invoicing and payment processing
• Identify, recommend, and implement automation or process improvements that enhance operational efficiency and employee experience
• Support HR policy development, ensuring alignment with Dyne’s culture and compliance with applicable laws and regulations
• Generate, analyze, and maintain accurate HR reports and dashboards by extracting data from HRIS and other systems to support strategic decision‑making, compliance, and operational efficiency
• Own the data submission of compensation benchmarking reports
• Assist with immigration‑related requests, documentation, and processes
• Assist with benefits administration

• Bachelor’s degree in Human Resources, Business Administration, or a related field
• 5+ years of HR or Talent operations experience, preferably within biotech, pharmaceutical, or high‑growth life sciences environments
• Hands‑on experience with ADP Workforce Now and Greenhouse ATS preferred
• Experience designing and managing onboarding programs that provide a seamless introduction to Dyne’s culture and mission
• Strong analytical and problem‑solving skills with attention to detail and data accuracy
• Excellent communication and organizational skills, with the ability to manage multiple priorities
• Demonstrated curiosity, continuous improvement mindset, and ability to drive process innovation
  
  Sense of urgency and intrinsic motivation to drive projects, generate solutions/ideas, and build knowledge and expertise

MA Pay Range: $118,340 – $145,500 USD. The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting.…