Senior Director, SOX Compliance

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Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Senior Director, SOX Compliance

Accounting

Waltham, MA (Hybrid 3 days per week)

Madrigal Pharmaceuticals is seeking an accomplished Senior Director, SOX Compliance to lead the company’s enterprise-wide Sarbanes‑Oxley (SOX) program. This role will be instrumental in updating Madrigal’s current control environment and ensuring a sustainable control framework that supports global commercial expansion and public company responsibilities.

• Maintain and enhance Madrigal’s SOX compliance program, including scoping, risk assessment, control design, documentation, testing, remediation, and ongoing monitoring.
• Partner with Finance, IT, Legal, HR, and business operations to ensure controls are properly designed and operating effectively across all key processes and systems.
• Lead the annual SOX risk assessment and control initiatives to ensure compliance efforts are efficient and aligned with business priorities.
• Lead annual internal and external process walkthroughs.
• Manage relationships with external auditors and consultants to ensure timely coordination of SOX testing and reporting.
• Drive continuous improvement of SOX‑related processes, automation opportunities, and control environment maturity.
• Lead RFP and implementation process for SOX software.
• Serve as the primary point of contact for SOX matters across the organization, including executive management and the Audit Committee.
• Communicate control deficiencies, testing results, and remediation progress in a clear, actionable manner to senior leadership.
• Partner closely with Finance and IT leadership to ensure alignment between control requirements, system implementations, and process changes.
• Provide strategic insight and guidance on internal control implications of new business initiatives, system implementations, and policy changes.
• Monitor evolving regulatory expectations, PCAOB standards, and best practices in internal control frameworks.
• Evaluate emerging risks and operational changes that could impact the control environment, proposing proactive mitigations where appropriate.
• Promote a strong control culture throughout the organization by training and mentoring control owners and stakeholders.

• Bachelor’s degree in Accounting, Finance, or related field; CPA or CIA required.
• 15+ years of progressive finance experience with 5+ years in SOX compliance, internal controls, and risk management—ideally including both public accounting and corporate experience in the biotech or pharmaceutical industry.
• Proven success building or transforming a SOX function within a complex, global organization.
• Deep knowledge of SOX 404 compliance, COSO frameworks, internal controls, and PCAOB standards.
• Strong understanding of IT general controls (ITGCs), automated controls, and system implementation risk.
• Exceptional communication and leadership skills with the ability to influence and align stakeholders across all levels of the organization.
• Demonstrated ability to build and mentor a high‑performing team and effectively manage external partners.
• Willingness to travel up to ~10% (domestic and international).

Base salary range: $245,000 – $299,000 per year. All full‑time employees receive equity, comprehensive benefits, and a 401(k) plan with employer match.

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.