Senior Director, Program Lead

Company Description Deciphera, a member of Ono Pharmaceutical Co., Ltd., is a biopharmaceutical company focused on discovering, developing, and commercializing important new medicines and providing hope to people living with cancer, neurologic and autoimmune disease. Deciphera is leveraging its proprietary switch-control kinase inhibitor platform and deep expertise in kinase biology to develop a broad portfolio of innovative medicines. In addition to advancing multiple product candidates from Deciphera’s platform in clinical studies, QINLOCK (ripretinib) is Deciphera’s switch-control kinase inhibitor approved in many countries including the European Union and the United States for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib.

ROMVIMZA (vimseltinib) is a kinase inhibitor approved in the United States for adult patients with symptomatic tenosynovial giant cell tumor (TGCT) for which surgical resection will potentially cause worsening functional limitation or severe morbidity, and in the European Union for adult patients with TGCT associated with clinically relevant physical function deterioration and in whom surgical options have been exhausted or would induce unacceptable morbidity or disability.
The spirit of collaboration that has brought medications to life continues to guide how we operate, grow, and discover new breakthroughs. We cultivate an inclusive culture that values curiosity, creativity, and shared accountability—empowering individuals to challenge the unknown together. Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

Job Description Deciphera’s cross-functional program teams drive the strategy and operations of our late preclinical, clinical, and commercial assets. We are seeking a dynamic, seasoned Sr Director, Program Lead (PL) who will be responsible and accountable for one or more therapeutic assets.  The successful candidate will be a strategic leader who can leverage their strong drug development expertise, EQ, and organizational skills to develop and drive the asset strategy and for leading all development and life-cycle management projects associated with the asset.

Key attributes of the successful candidate include:

Key Responsibilities:

Program Strategy & Execution Accountability For a given asset/program, responsible for the development and execution of the overarching global program strategy. The PL leads all research and development activities associated with an asset from approximately nomination of lead candidates to the marketplace with full accountability.

Drive the development and execution of the strategic plan, appropriately balancing data quality, timelines and costs based on current internal corporate considerations and the external landscape.

Lead one or more cross-functional program teams to define program vision, strategy, goals, decision points, investments and areas of risk and associated mitigations and contingencies.

Partners closely with the program manager to provide strategic, process and operational leadership to the Program team Identifies and communicates risks and appropriate mitigations

Lead data-driven decision-making processes to enable timely and objective development decisions

Communicate Holistic and confident communication: ensure PT clearly understands expectations from leadership, ensure leadership clearly understands program status, timelines, milestones, risks and mitigations

Focus team…