Postdoctoral Researcher, Quantitative Systems Pharmacology

Postdoctoral Researcher, Quantitative Systems Pharmacology – Fixed Term Contract

Location:

Hertfordshire, UK (Stevenage), Waltham, MA, USA

Posted on Jan 2, 2026

The Clinical Pharmacology and Quantitative Medicine (CPQM) group in Respiratory, Immunology and Inflammation Research Unit, R&D GSK is recruiting for a Postdoctoral researcher in Quantitative Systems Pharmacology (QSP) to join their CPQM QSP team.
CPQM at GSK is a newly established organization with the remit to become a Centre of Excellence in Model-Informed Drug Development (MIDD). It uniquely integrates clinical pharmacology, digital medicine, translational imaging, and mechanistic & systems modelling.

This industrial QSP Postdoc position represents a unique opportunity for those with a PhD, MD, Pharm

D, or equivalent doctoral background, who have previous experience in mechanistic mathematical modelling to gain pharmaceutical industry experience of applying systems modelling and computational methodologies to drug discovery and development to advance the vision and mission of GSK’s rapidly expanding Respiratory, Inflammation and Immunology Disease portfolio.

Benefits:
Competitive salary, annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, shares and savings programme. Hybrid working model offered through Performance with Choice programme.

• Build mechanistic mathematical models of biological, physiological, and pathophysiological processes to evaluate disease and drug action, including simulation of virtual patients to inform target and/or asset prioritisation and optimal trial design.
• Develop and/or utilise state‑of‑the‑art mathematical tools, including knowledge of non‑linear dynamics, scientific ML and statistical techniques to gain insight into causal relationships between individual components of system‑level and drug‑level responses.
• Identify relevant questions by working with disease area experts across different disciplines and address them by applying mechanistic and systems modelling.
• Collaborate closely with clinicians, biologists, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker and genomics scientists to inform R&D programmes and improve our understanding of disease mechanisms.
• Promote transparency and communicate R&D achievements through publications in appropriate scientific journals.

• PhD, MD, or Pharm
  
  D with experience in mechanistic modelling, simulation, and systems biology.
• Strong drive to quickly learn and build knowledge on a drug‑disease system, mechanisms, endpoints, progression, prevention, treatments, and trial design.
• Strong communication skills and demonstrated ability to work in a multi‑discipline team, taking accountability for timely delivery of results.
• Prior experience with applications in pharmaceutical R&D is a plus.
• Prior experience in Respiratory (e.g., COPD, IPF), Renal (e.g., CKD, nephrotoxicity), Hepatology (e.g., MASH) and/or Infectious diseases (e.g., HBV) is a plus.

Closing Date for Applications – 16th January, 2026 (COB).

GSK is an Equal Opportunity Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any other basis prohibited under federal, state or local law.

If you require adjustments to the recruitment process, please contact UKRe (you may also request a call).