Senior Scientist Genomic Medicine BioAnalytics Characterization

Position: Senior Scientist Genomic Medicine BioAnalytics Characterization
Job Title:

Senior Scientist Genomic Medicine Bio Analytics Characterization

Location:

Waltham, MAAbout the Job:

We are seeking a motivated Senior Scientist to join our Bio Analytics Characterization group in the Genomic Medicine Unit within Sanofi. Candidates with no previous experience in the field of genomic medicine are still encouraged to apply – we are looking primarily for someone with strong mass spectrometry characterization experience and are committed to bridging any knowledge gaps through dedicated onboarding and training.

This role offers a unique opportunity to build expertise in the rapidly growing field of genomic medicine, including viral gene therapies and lipid nanoparticles. The future of medicine is being shaped today at Sanofi — apply now and position yourself at the forefront of the next generation of transformative therapeutics. The Genomic Medicine Unit at Sanofi is dedicated to the establishment of best-in-class platforms to support development of life-changing advanced gene therapy products.

The Bio Analytics Characterization group uses advanced analytical techniques for in-depth structural and functional characterization of gene therapy products in support of drug development, from pre-candidate selection through commercialization. Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions

About Sanofi:
We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives

Main responsibilities:

Develop and implement advanced characterization strategies for gene therapy candidates, including viral vectors and nonviral particles Utilize a robust and sensitive LC-MS platform to profile HCP clearance throughout purification process and quantitatively monitor impurities of concern to support CMC product development  Establish HCP impurity method detection limits and precision, and oversee transfer and comparability to automated sample preparation methods within facility Utilize LC-MS proteomics platform in profiling differential protein expression in cell lysates to support Cell Culture Process Development  Develop LC-MS characterization methods of nonviral particles including RNA impurity determination and oligonucleotide mapping Collaborate cross functionally and support process/formulation development through comprehensive LC-MS characterization (peptide mapping, HCP analysis, and oligonucleotide analysis) Establish new end-to-end automated data workflows (e.g. from data upload and application specific data processing to reporting in ELN) Author technical documentation including reports, protocols, and regulatory filings (IND/IMPD/BLA) Contribute to scientific literature and present at internal and external conferences

About You:

Education:

Ph.D. in Biochemistry or Chemistry-life science related field, OR M.S. with 4+ years of industry experience Experience & Technical

Skills:

Extensive LC-MS experience in protein characterization, identification and protein quantitation  Proficiency with Thermo and/or AbSciex instruments and at least one peptide mapping/proteomics software such as Spectronaut, Genedata Expressionist, Protein Metrics, Skyline, or Proteome Discoverer Demonstrated success implementing novel analytical technologies

Preferred Qualifications:

Experience with automation and AI-driven analytical workflows is highly desirable.

Professional

Skills…