Scientist, Peptide Purification

Amide Technologies is a Massachusetts-based biotech company focused on synthesizing peptides and proteins that are difficult to obtain through existing means, bridging the gap between traditional solid phase peptide synthesis and biological expression. By using unnatural amino acids and artificial protein backbones, our team is expanding possibilities in peptide drug design. Our team members face and conquer unique challenges because Amide makes compounds which have never been made before.

If you are seeking to push scientific boundaries and gain unparalleled experience in your field, consider applying for the role below.

Amide is seeking an exceptional individual to join our growing team as a Scientist or Senior Scientist, Peptide Purification. As a key member of the purification team, the candidate will discover and apply innovative chromatography principles and techniques. The candidate will also collaborate closely with experts in biology, chemistry, artificial intelligence, and business development.

• Purify and analyze synthetic peptides and proteins (1-15 kDa, with a variety of chemical modifications such as fatty acid chains, biotinylation, fluorophores, disulfides, small molecule conjugates etc.) using RP‑HPLC and LCMS instrumentation
• Collaborate closely with the synthesis team to diagnose complicated crude mixtures, identify synthetic byproducts, and develop strategies to isolate difficult impurities.
• Troubleshoot and optimize challenging purifications, including sequences with poor solubility, aggregation tendencies, or unusual chromatographic behavior.
• Optimize and accelerate chromatographic methods for purifying a wide range of polyamides with differing properties
• Drive innovation in purification automation, including improved fraction handling, screening workflows, and data management
• Contribute to ongoing innovation within the company through the introduction of new chromatography trends, technologies, and resin/column chemistries
• Meticulously record, analyze, and organize data for use in presentations to the purification team and leadership teams

• Degree in chemistry, chemical biology, biochemistry, or related field
• Scientist:
  PhD in Chemistry or Masters with 2+ years of purification experience
• Senior Scientist:
  PhD with 4+ years of purification experience
• Experience with solid‑phase peptide synthesis and modification
• Experience purifying peptides or other biopolymers
• Experience with HPLC, FPLC and LC‑MS instrumentation
• Experience working in matrixed teams of scientists to meet project objectives
• Demonstrated effective problem‑solving skills
• Strong organizational skills and communication across teams

The position is full time and the Scientist/Senior Scientist, Peptide Purification will be based at the company’s headquarters in Waltham, Massachusetts, USA. Flexibility with regard to working hours and travel is required. Scientist/Senior Scientist, Peptide Purification will report to the Chief Executive Officer.

Amide Technologies offers a challenging and exciting role in one of the Northeast’s most innovative biotech companies. The company offers a competitive compensation package including salary, bonus and equity.

Amide deeply values diversity and is committed to creating an inclusive environment for all employees. We are an equal opportunity employer. We consider all qualified applicants equally for employment. We do not discriminate on the basis of race, color, national origin, ancestry, citizenship status, protected veteran status, religion, physical or mental disability, marital status, sex, sexual orientation, gender identity or expression, age, or any other basis protected by law, ordinance, or regulation.