Associate Director, Bioconjugation & Delivery

About Alloy Therapeutics

We are Alloy Therapeutics—a biotechnology ecosystem company empowering the global scientific community to make better medicine together. Through a community of partners, we democratize access to pre‑competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non‑exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100 % of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.

Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK;
Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

This is an on‑site and full‑time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship‑By‑Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face‑to‑face.

The Alloy Genetic Medicines group is innovating a novel RNA‑based drug discovery platform, namely “Anti Clastic”, spanning the fields of antisense therapeutics to immunomodulating therapeutics. This technology platform was launched by Alloy in 2023 after exclusively licensing its underlying intellectual property which implements a novel spatial conformation of the oligonucleotide developed by Sudhir Agrawal of Arnay Sciences. The team works closely with external partners to discover and develop Anti Clastic RNA medicines.

Alloy Therapeutics is seeking a visionary and technical leader to serve as the subject matter expert for Bioconjugation and Delivery within our Genetic Medicines Unit. Whether you are a seasoned manager or an elite independent contributor, you will play a pivotal role in bridging the gap between innovative nucleic acid chemistry and transformative therapeutic delivery.

You will be responsible for the end‑to‑end development, documentation, and implementation of process and analytical pipelines for Antibody Oligonucleotide Conjugates (AOCs) and targeted Lipid Nanoparticles (LNPs). This role requires a rare blend of deep technical mastery in conjugation chemistry and a strategic understanding of Quality by Design (QbD) to drive our internal programs and external partnerships forward.

• Process Leadership:
  Design and execute robust bioconjugation pipelines for AOCs (utilizing ASOs, siRNA) and targeted LNPs. This includes conjugating oligonucleotides, lipids, and nanoparticles to various targeting domains such as peptides, proteins, and aptamers.
• Innovation:
  Drive innovation to improve circulating half‑life, tissue penetration, cellular uptake, and intracellular bioavailability of payloads.
• Method Development & Analytics:
  Establish high‑resolution analytical methods and pipelines. Directly responsible for developing and proceduralizing in‑process testing and finished product QC using HPLC (SEC, IEX, IPRP) and LC‑MS.
• QbD & Documentation:
  Operate within Quality by Design framework, maintaining meticulous records in our Electronic Lab Notebook (ELN). Iterate between product descriptions and process knowledge to ensure scalable, high‑quality manufacturing.
• Supply Chain & Quality:
  Lead the review of raw materials and their quality attributes. Define process descriptions and manage technologies required for successful process scale‑up.
• Cross‑Functional
  
  Collaboration:
  
  Act as a central pillar within Genetic Medicines and Alloy, collaborating seamlessly with the Nucleic Acid Chemistry and Biology groups. Serve as a primary technical point of contact for external partners.
• Thought…