Principal Scientist​/Associate Director​/Director, Clinical Science

Principal Scientist/Associate Director/Director, Clinical Science

Join us to apply for the Principal Scientist/Associate Director/Director, Clinical Science role at Acrivon Therapeutics, Inc.

Acrivon (NASDAQ: ACRV) is a clinical stage biopharmaceutical company discovering and developing precision medicines utilizing its proprietary Generative Phosphoproteomics AP3 platform. The AP3 platform enables the company to interpret and quantify compound‑specific, drug‑regulated pathway activity levels inside intact cells in an unbiased manner, yielding terabytes of proprietary data and delivering rapid, actionable insights. The platform includes a suite of internally developed tools that transform multimodal data into structured data for generative AI analyses, and delivers highly differentiated compounds with desirable pathway effects through intracellular protein network analyses.

Acrivon is currently advancing its lead program, ACR-368 (prexasertib), a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2b trial for endometrial cancer. The company received Fast Track designation from the FDA and a Breakthrough Device designation for the ACR-368 Onco Signature assay.

In addition to ACR-368, Acrivon is leveraging the AP3 platform to develop its co‑crystallography‑driven pipeline programs, including ACR-2316, a potent WEE1/PKMYT1 inhibitor in Phase 1 studies. The company operates from Watertown, MA and Medicon Village, Lund, Sweden.

The Principal Scientist/Associate Director/Director is a key member of the Clinical Development team and will assist our clinical science efforts with.

• Support the development of two clinical‑stage assets (ACR-368 and ACR-2316).
• Drive real‑time analysis and monitoring of emerging clinical data (safety and clinical activity).
• Contribute to future clinical studies in all phases of design, data collection, interpretation, and visualization for corporate presentations.

Watertown, MA (Corporate Headquarters)

• Collaborate with the Clinical Development Team on review, analysis, and interpretation of study results, ensuring accurate reporting, query closure, database quality, safety event and protocol deviation oversight, and tracking of study‑related samples and reports.
• Develop powerful presentations (waterfall, swimmer, spider plots, etc.) to communicate study data to internal and external audiences.
• Support database control and integrity, data and sample tracking, regulatory responses, query issuance, and adherence to GCP and company standards.
• Work closely with the medical monitor to keep them informed of pertinent study information.
• Proactively identify study or program challenges by reviewing emerging clinical data related to safety, efficacy, protocol deviations, site performance, and query management.
• Develop and implement solutions to identified issues in collaboration with the clinical study team and CROs.
• Conduct literature reviews as needed for interpretation of data and development of next steps.
• Collaborate with internal/external experts on biostatistics, clinical pharmacology, translational medicine, operations, and data management to contribute to trial design and regulatory documents.
• Support development of additional program documents (pharmacy manuals, SOPs, safety tracking, SIV materials).
• Prepare clinical sections for regulatory submissions (INDs, clinical study reports, investigator brochures, NDAs).
• Serve as a clinical science representative on cross‑functional teams.

• Advanced degree in a life science field (PhD or Pharm
  
  D).
• Minimum of 4 years (Principal), 7 years (Associate Director), or 10 years (Director) of relevant clinical research experience in pharmaceutical/biotech companies or clinical trial organizations. Direct translational experience is desirable.
• Experience executing and interpreting early, mid, and late stage oncology clinical studies with diverse trial endpoints, including biomarker and quality‑of‑life assessments.
• Experience managing and tracking clinical data and critically reviewing study documents with exceptional attention to detail.
• Experience working with and managing CROs; experience in joint research collaborations is desirable.
• Outstanding oral and written communication skills and ability to work efficiently with multidisciplinary teams across geographic locations.
• Demonstrated strong IT skills, including Microsoft Office Suite, SharePoint, Egnyte, Zoom, MS Teams, etc.
• Deep expertise with one or more data visualization platforms (Spotfire, Tableau, Prism, etc.) for key clinical graphs. Programming experience (R, Python, SAS) is desirable but not required.

Mid‑Senior level

Full‑time

Research, Analyst, and Information Technology

Pharmaceutical Manufacturing and Biotechnology Research