Manager or Sr. Manager, Clinical Trial Feasibility Lead

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions.

Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit  or follow us on X (formerly Twitter) or Linked In. How we work:

PIONEER:
We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.

COLLABORATE:
We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.

BELONG:
We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

We are seeking a highly motivated Manager or Senior Manager, Clinical Trial Feasibility Lead to own feasibility assessment and country and site strategy within the Kymera Trial Optimization function. This individual will lead the feasibility process for clinical studies across the portfolio, working with cross-functional study teams, Development Operations, and CRO partners to ensure protocols, country and site plans, and enrollment assumptions are realistic, evidence-based, and executable.

The role draws on patient population and epidemiology information, site and investigator insights, historical study experience, and the competitive trial landscape to shape study planning and strategy. Reporting to the Director of Clinical Trial Planning and Feasibility, the individual will translate feasibility findings into clear recommendations at the study team level that improve the speed and predictability of clinical trial execution.

Lead end-to-end feasibility for clinical studies, from early protocol concept through site selection, assessing recruit ability, patient availability, site capacity, and operational risk to inform study design and planning.

Develop country and site recommendations, including country allocation, site footprint, and site selection criteria, in collaboration with Clinical Operations and CRO partners.

Oversee site feasibility activities with CROs and vendors, including site and investigator outreach, feasibility questionnaires, and the evaluation of site capabilities, patient access, and prior experience with similar studies.

Establish and communicate enrollment and recruitment assumptions, including enrollment timelines, screen failure and dropout expectations, and site activation plans, and define the key feasibility risks and mitigation strategies for each study.

Assess the competitive clinical trial landscape to understand competing studies, patient and site competition, treatment landscape dynamics, and other factors that may affect study feasibility and enrollment.

Partner with the Kymera Site Engagement team to obtain real-world insight into patient populations, standard of care, and site operations.

Monitor study performance against feasibility assumptions, including enrollment and site activation, and work with study teams and CROs to identify emerging risks and recommend recruitment and contingency strategies.

Capture lessons learned and feedback between planned and actual trial performance to…