Scientist II, Cell Pharmacology

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Cell Pharmacology Full Time Technical Watertown, MA, US

Today Requisition

Salary Range: $ To $ Annually

About C4 Therapeutics:

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transform patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes.

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Job Summary

C4 Therapeutics is seeking a scientifically motivated Research Scientist II to join the Cell Pharmacology group within Lead Discovery. In this hands‑on role, you will develop and execute robust cell‑based assays to inform screening, compound profiling, structure–activity relationships, and discovery program progression in targeted protein degradation. Working closely with colleagues across Lead Discovery, Biology, Medicinal Chemistry, and other functions, you will tackle challenging scientific questions and translate rigorous experimentation into program decisions.

The role offers scientific ownership, access to advanced technologies, and opportunities to expand your technical and drug discovery expertise in a collaborative environment that values independence, curiosity, open communication, and diverse perspectives—all while helping advance medicines with the potential to transform patients’ lives.

Your Role

• Develop, optimize, validate, and execute fit‑for‑purpose cell‑based assays for screening, hit confirmation, compound profiling, mechanism‑of‑action studies, and SAR progression.
• Apply HiBiT, HTRF, and Cell Titer‑Glo technologies to measure protein degradation, pathway modulation, viability, and related pharmacology endpoints.
• Independently culture, characterize, bank, and troubleshoot mammalian cell lines; engineer cellular models using stable or transient expression and genome‑editing approaches.
• Plan rigorous experiments with appropriate controls and performance criteria; identify and resolve assay and cell‑line issues.
• Process, analyze, visualize, interpret, and document screening and pharmacology data; translate findings into recommendations for compound and project decisions.
• Proactively communicate data, progress, risks, and next steps through timely updates, presentations, and cross‑functional discussions.
• Maintain accurate experimental records and contribute to laboratory safety, organization, reagent stewardship, technology evaluation, and continuous improvement.
• As needed, support CRO activities including assay transfer, protocol review, troubleshooting, timeline coordination, and data‑quality assessment.

Your Background

Required:

• A PhD in cell biology, molecular biology, cancer biology, pharmacology, biotechnology, or a related discipline, with at least two years of relevant post‑PhD research experience or a Master’s Degree with at least three years of relevant post‑graduate experience.
• Expertise developing and executing multi‑well cell‑based screening and profiling assays; hands‑on proficiency with HiBiT, HTRF, and Cell Titer‑Glo, including optimization, controls, performance assessment, and troubleshooting.
• Experience with medium‑or high‑throughput…