Research Scientist - Pradhan-Sundd Lab

Research Scientist I - Pradhan‑Sundd Lab

Located in Milwaukee, Wisconsin, the Versiti Blood Research Institute (VBRI) is the largest blood‑focused research institute in the United States. With over 30 basic, translational, and clinical investigators, the institute is dedicated to advancing scientific knowledge and developing innovative therapies related to blood and blood disorders. The institute’s research interests encompass a wide range of topics, including transfusion medicine, cellular therapy, thrombosis/hemostasis, immunology, and hematologic malignancies.

As a vital part of Versiti, a non‑profit organization with a blood bank at its core, the VBRI strives to improve lives through innovative research and the development adaptaivalent of novel diagnostics and treatments.

VBRI is part of the Milwaukee Regional Medical Campus, a rapidly growing clinical‑translational research hub. VBRI’s proximity to the Medical College of Wisconsin, Children’s Hospital of Wisconsin, and Froedtert Hospital facilitates seamless interdisciplinary collaborations. Construction of a new research building, which began in summer 2024, will double existing VBRI research space and enable the recruitment of 10‑15 new faculty. With renowned researchers, a strategic expansion plan, and a collaborative environment, VBRI is poised to maintain and expand its position as one of the world’s leading hematology institutes.

Develops and elucidates scientific aims, experimental design, and execution. A Research Scientist I is equivalent to the Research Assistant Professor position at many universities.

Hemolysis is a key characteristic of sickle cell disease (SCD) that contributes to the disease pathogenesis and clinical heterogeneity. In SCD, cell‑free hemoglobin and its byproducts (heme and iron) cause vasculopathy as well as a slew of clinical consequences, including liver failure. Although liver injury affects up to ~40% of hospitalized SCD patients, therapeutic approaches to prevent liver injury in SCD are limited.

In the Pradhan‑Sundd lab we are interested in understanding the molecular signaling mechanisms of hemolysis‑induced acute and chronic liver injury. We also investigate the processes of hepatic hemoglobin доставки heme, and iron clearance in SCD.

Hemophilia A is an X‑linked recessive bleeding disorder caused by the absence of coagulation factor‑VIII (FVIII). Individuals who are affected are at risk of spontaneous bleeding into joints which can be life threatening. Recent advances in liver‑directed gene transfer suggest that gene therapy can successfully treat hemophilia

A. FVIII is produced in the liver sinusoidal endothelial cells. Thus, liver sinusoidal endothelial cell viability and functioning are important for successful liver directed gene transfer in hemophilia. We have recently shown liver sinusoidal endothelial maladaptive structural changes in FVIII‑deficient mice and their deleterious impact on the efficacy of liver‑directed gene transfer. Abnormal endothelial function has recently been recognized in patients with hemophilia

A. Our current research focuses on investigating the molecular mechanisms that contribute to the loss of endothelial fenestration in individuals with FVIII deficiency, and how this loss impacts liver‑directed gene therapy in patients with hemophilia.

Versiti provides a comprehensive benefits package based on your job classification. Full‑time regular employees are eligible for medical, dental, and vision plans, paid time off (PTO) and holidays, short‑ and long‑term disability, life insurance, 7% match dollar‑for‑dollar 401( k), voluntary programs, discount programs, and other benefits.

• With direction from PI, assists in designing goal‑oriented, hypothesis‑driven research program(s)
• Takes advantage of opportunities to apply for local or national grants asurkan applicable to fund relevant research
• Experimental work and data analyses
• Maintains an active scientific publication and…