Associate Director​/Director, Program Manager, CLYM

Climb Bio is a clinical-stage biotechnology company developing therapeutics for patients with immune-mediated diseases. Our product candidates include budoprutug, an anti-CD19 monoclonal antibody that presents us with an exciting opportunity given its broad potential applicability across a number of B-cell mediated diseases, including systemic lupus erythematosus, immune thrombocytopenia, and membranous nephropathy and CLYM
116, an anti-APRIL monoclonal antibody in development for IgA nephropathy.

At Climb Bio, our team has a knack for seeing what no one else sees — and a drive to achieve results no one expects. We believe that our combined strength conquers any summit, and our core values – Build Trust, Decide & Commit, Accelerate Impact, and Mark the Moment – guide how we work, collaborate and innovate. They reflect our commitment to patients, each other, and the pursuit of transformative science.

This is a cross-functional role accountable for translating the CLYM
116 asset strategy into an integrated execution plan and for driving day-to-day delivery against it. Reporting to the CLYM
116 Program Leader, the Program Manager owns the program's integrated timeline, risk management, and operating rhythm — ensuring the program team stays aligned, decisions are made and documented, and commitments are delivered. The role partners closely with Clinical Development, Clinical Operations, Regulatory, CMC, Nonclinical, Quality, Finance, and Commercial, and supports the Program Leader in managing the collaboration with our development partner.

The ideal candidate brings strong execution, forward-planning, and facilitation skills, and uses AI tools and integrated systems to scale how the program team plans, tracks, and communicates.

• Translate the CLYM
  116 Integrated Development Plan (IDP) into an integrated program timeline and own it end to end — building and maintaining the detailed schedule, interdependencies, critical path, and resourcing across all functions, and leading day-to-day execution against it in partnership with the Program Leader.
• Maintain a shared, current view of program commitments and status, from regulatory interactions and ongoing clinical studies through registrational development and launch readiness.
• Prepare regular program updates for leadership and develop materials supporting Board presentations, translating program status, risks, and decisions into clear, concise messages.
• Lead forward planning and scenario analysis — timeline, enrollment, study design, and investment options — to frame trade-offs and inform program team, Leadership Team, and Board decisions.
• Manage program-level risks, issues, and dependencies; drive mitigation and contingency plans and elevate to the right forum at the right time.
• Run the program team operating rhythm, including agendas, pre-reads, decision and action logs, minutes, and follow-through, ensuring discussions move to decisions and decisions move to action.
• Partner with the Program Leader to implement program governance processes, decision frameworks, and accountability mechanisms, and prepare the program for governance forums with clear asks, options, and recommendations.
• Integrate study-level plans and status from Clinical Operations (including the Clinical Program Lead) into the program plan, and align workstream plans and dependencies with CMC, Regulatory, and Nonclinical.
• Support the Program Leader in managing the partner collaboration — coordinating joint governance (JSC, JDC, and working groups), tracking actions, contract milestones, and deliverables, and surfacing issues early.
• Partner with the Program Leader, functional leaders, and…