Associate Principal Scientist, Drug Metabolism & Pharmacokinetics

Job Description

The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our Research & Development Division in West Point, Pennsylvania, is seeking 2 dynamic and collaborative scientists for the Drug Metabolism and Pharmacokinetics (DMPK) group. The Associate Principal Scientist will be a key contributor to multi‑disciplinary drug discovery and development efforts, providing an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk of novel therapeutics.

The key responsibilities include working on teams of highly collaborative, cross‑functional scientists to discover and develop therapeutics across various modalities. The Associate Principal Scientist will design and interpret in silico, in vitro, and in vivo analyses to support the discovery of therapeutics with the desired DMPK profile. They will assess DDI risk using static mechanistic and/or physiologically based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy.

They will author source reports and documents in support of regulatory filings. They will independently evaluate and predict potential program risks, while implementing appropriate strategies to address liabilities to ensure efficient program progression and decision making.

The ideal candidate must be able to work collaboratively in a fast‑paced environment, drive scientific development and innovation, and have excellent interpersonal and communication skills. Experience supporting both small molecule and biologics (e.g. antibodies and drug conjugates) programs is desired.

• Bachelor’s, Master’s, or PhD degree in Pharmaceutical Sciences, Pharmacology, Chemistry, Biomedical Engineering, Biochemistry, Biology, Biophysics, Biostatistics, or relevant STEM fields.

• 10+ years of industry experience with a Master’s degree, 8+ years with a Master’s or PhD with 5+ years focused on discovery and development of therapeutics across modalities including small molecules, antibodies, and drug conjugates.
• Strong leadership, interpersonal, communication, problem solving, and collaboration skills, while delivering results on firm deadlines.
• Experienced in integrating preclinical DMPK and pharmacology to enable translational modeling and simulation to support dose selection, design of PK/PD and safety assessment studies, and dose justifications for preclinical and clinical studies.
• Experience in assessing the impact of various factors on the pharmacokinetics and pharmacodynamics of novel therapeutics and communicating analyses and recommendations to interdisciplinary teams and management.
• Experience with authoring documents in support of IB, IND, WMA filings, and responses to regulatory inquiries.
• Demonstrated track record as an effective collaborator on multi‑disciplinary discovery and development teams.

• Strong publication track record
• Experience representing the DMPK function in the evaluation of third‑party assets.
• Experience building models and performing analyses using Phoenix and PBPK modeling software (e.g., SimCYP).
• Experience mentoring or supervising junior staff.

• ADME
• Bioanalytical Techniques
• Cell‑Based Assays
• Communication
• DMPK
• Drug Interactions
• Drug Metabolism
• Liquid Chromatography‑Mass Spectrometry (LC‑MS)
• Mentorship
• Pharmacodynamics
• Pharmacokinetics
• PKPD Modeling
• Project Leadership
• Strategic Thinking

• Current Employees apply
• Current Contingent Workers apply

Salary Range: $ - $

Benefits include medical, dental, vision, health insurance for employee and family, retirement benefits including 401(k), paid holidays, vacation, and compassionate and sick days. More information is available through the company compensation and benefits portal.

Apply for this role through the company career site. The Final date to receive applications for this position is stated on this posting.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit the EEOC website.