Associate Director, IO; immuno-oncology​/immunology

Associate Director, IO (immuno‑oncology/immunology)

ModeX Therapeutics is an OPKO Health company and a leading clinical‑stage biopharmaceutical company that develops unique and proprietary multispecific therapeutics. Their MSTAR platform allows a single molecule to combine the power of multiple biologics, creating antibodies that bind four or more targets with unprecedented versatility and potency for complex diseases. Their first‑in‑class immunology pipeline targets immune diseases, including both solid and hematologic tumors, immune impairment, and several major viral threats.

ModeX is headquartered in Weston, Massachusetts.

ModeX Therapeutics is seeking a highly skilled and motivated Associate Director with experience in immuno‑oncology/immunology to support the development and progression of new immune therapies. The successful candidate will work with ModeX's team to test novel biologic drug candidates, delineate their mechanism of action, and address biological questions. This is an exciting opportunity to be part of a cross‑functional team and contribute to the development of next‑generation therapeutics in a fast‑paced, rapidly growing biotech company with a bold vision.

• Provide strategic and scientific leadership for early‑stage discovery programs in Immuno‑Oncology and Immunology & Inflammation, from target identification and validation through lead optimisation and IND‑enabling studies.
• Identify, validate, and advance novel therapeutic targets and mechanisms that align with the company's pipeline strategy.
• Design and implement research strategies that drive innovation and support therapeutic area and corporate objectives.
• Lead and mentor a team of scientists and research associates, fostering an inclusive, high‑performing, and collaborative culture.
• Oversee in vitro and in vivo studies to characterise immune pathways, assess target engagement and pharmacology, and generate translational data supporting IND‑enabling activities.
• Ensure scientific rigor and innovation in experimental design, data interpretation, and decision‑making at key programme milestones.

• Ph.D. in Immunology, Immuno‑Oncology, or a related discipline.
• 8–10+ years of relevant research experience, including at least 5 years in a biotech or pharmaceutical R&D environment.
• Extensive expertise in Immuno‑Oncology and Immunology/Inflammation disease biology, supported by a demonstrated track record of advancing therapeutic programmes and a strong scientific publication record.
• Proven leadership in early‑stage drug discovery, including target identification and validation, in vivo/ex vivo pharmacology, and IND‑enabling studies.
• Demonstrated ability to lead, mentor, and develop high‑performing scientific teams in a fast‑paced, collaborative environment.
• Excellent organisational, communication, and interpersonal skills, with the ability to effectively influence and collaborate across multidisciplinary, matrixed teams.
• Demonstrated ability to think strategically, adapt to change, and drive innovation in a dynamic research environment.