Research Scientist - Protein Science and Technology

As a Research Scientist you will be joining the world’s largest & most comprehensive clinical research organisation, powered by healthcare intelligence. We are looking for a motivated scientist with experience in recombinant protein production to join our structural biology team. In this role, you will be responsible for expressing, purifying, and characterizing recombinant proteins and complexes to support Cryo-EM and Crystallography studies.

• Protein Expression:
  Transfection of plasmids into mammalian cells and cell line maintenance, generation of baculovirus and expression of proteins in Sf9 cells, expression of proteins in bacterial systems. Good experience expressing proteins is very important for this position.
• Protein Purification:
  Design, optimize, and execute protocols for the purification of recombinant proteins using commonly applied chromatography techniques (e.g., affinity, ion exchange, size exclusion).
• Biophysical Characterization:
  Perform biophysical characterization of purified proteins, including but not limited to analytical SEC, Differential Scanning Fluorimetry (DSF), Thermal Stability Assays.
• Data Analysis & Reporting:
  Maintain detailed records of experimental designs, data, and results. Analyze and interpret data for presentation to key stakeholders.
• Team
  
  Collaboration:
  
  Work closely with structural biology team to determine protein constructs with optimal stability and functionality.
• Daily operations:
  Help the daily operations of the protein production team, maintaining a highly productive protein production laboratory, performing small- and large-scale expression and purification experiments, characterization of samples, and contributing to development of the lab.
• Strategy development:
  As a team member, develop and implement short and long-term strategies to enhance protein production capabilities.
• Vectors and cloning:
  Good understanding or experience with vectors and cloning strategies needed for protein expression in different cell systems.
• Troubleshooting:
  Help troubleshooting recombinant protein expression to maximize protein yield.
• Independent work:
  Ability to work independently (but under guidance) to deliver high quality purified protein samples and complexes for structural studies.
• Workflows:
  Ability to efficiently and reproducibly follow established workflows.
• Cryo-EM and Crystallography:
  Cryo-EM and Crystallography experience is highly desirable but not required.

• BS/MS with a minimum of 2-3 years of experience.
• Proven experience supporting drug discovery programs using structural biology and biochemistry is desirable.
• Good communication and interpersonal skills.
• Proven experience working with matrix teams.
• Self-driven, creative and entrepreneurial with ability to support multiple programs simultaneously.
• Office based in Wilmington, DE

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent. In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family’s needs
• Competitive retirement planning offerings to maximise savings and plan with confidence for the years ahead
• Global Employee Assistance Programme, TELUS Health, offering 24-hour access to a global network of over 80,000 independent specialised professionals who are there to support you and your family’s well-being
• Life assurance
• Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidised travel passes, health assessments, among others

Visit our careers website to read more about the benefits of working at ICON.

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is…