Senior Scientist, Automated Synthesis Put Chemistry

A global biopharmaceutical company on a mission to Solve On, Incyte follows science to find solutions for patients with unmet medical needs. Through the discovery, development, and commercialization of proprietary therapeutics, Incyte has established a portfolio of first-in-class medicines for patients and a strong pipeline of products in Hematology, Oncology and Inflammation and Autoimmunity

Headquartered in Wilmington, Delaware, Incyte has operations in North America, Europe, and Asia.

Discovery Accelerator Laboratories at Incyte is seeking an experienced parallel synthesis chemist to lead automated chemistry operations and the synthesis of parallel compound libraries. As a member of the Discovery Chemistry organization, this role will focus on developing and implementing automated synthesis workflows, high-throughput experimentation and reaction optimization strategies to accelerate drug discovery programs.

The successful candidate will bring a strong background in synthetic organic chemistry, parallel library synthesis, laboratory automation, and robotics, with demonstrated expertise in programming and operating Chemspeed platforms. This individual will work closely with medicinal chemists, computational and AI scientists, analytical chemists and informatics teams to enable efficient, scalable, and data-rich chemistry workflows.

• Collaborate with Medicinal Chemistry project leaders, computational chemists, and AI scientists to identify, prioritize, and design high-value chemical libraries that address project hypotheses and expand structure–activity relationships (SAR).
• Program, configure, operate, and maintain automated synthesis workstations, including Chemspeed FLEX/ISYNTH and SWILE platforms using Auto Suite, for parallel reaction setup, liquid and solid dispensing, reaction execution, and automated workup.
• Design and execute targeted parallel synthesis campaigns spanning multi-gram intermediates to milligram final compounds to support SAR development across discovery programs.
• Develop and optimize microscale high-throughput experimentation workflows for reaction screening, catalyst and reagent evaluation, and reaction‑condition optimization.
• Translate conventional synthetic procedures into robust, reproducible, and scalable automated workflows suitable for parallel execution.
• Calibrate, maintain, and troubleshoot automated hardware components, including gravimetric powder-dosing systems, liquid‑handling modules, viscous‑liquid dispensers, temperature‑control systems, and parallel reactors.
• Develop and optimize automated downstream processing workflows, including liquid–liquid extraction (LLE), solid‑phase extraction (SPE), filtration, solvent exchange, and parallel evaporation.
• Capture, structure, and integrate experimental and workflow execution data within Electronic Lab Notebooks (ELN), LIMS, and internal data systems in collaboration with informatics and computational teams.
• Partner with Analytical Chemistry and Purification groups to establish integrated workflows for LC‑MS/SFC analysis, purification, sample management, and plate‑based compound dispatch.
• Evaluate and implement emerging automation technologies, synthetic methodologies, and workflow improvements that increase throughput, reproducibility, data quality, and operational efficiency.
• Provide technical leadership and training to scientists using automated synthesis and HTE platforms and contribute to laboratory best practices, documentation, and operational standards.

• Ph.D. in Organic Chemistry or a related discipline with 5+ years of relevant…