Researcher, Healthcare, Clinical Research

Researcher – Cancer Biology

Department: CCC | Sponsored Research

We are seeking highly motivated and enthusiastic Ph.D. or MD scientists to join our group as postdoctoral research fellows. The position is in the laboratory of Dr. Triparna Sen at the Department of Internal Medicine, Division of Medical Oncology at The Ohio State University. The lab focuses on mechanisms of initiation, progression, and therapeutic resistance in lung cancer, utilizing high‑throughput screening, genomics, proteomics, metabolomics, clinical samples, and animal models to develop novel therapeutic strategies.

The Researcher will be a core technical member of the lab, supporting all aspects of translational research with a focus on CRISPR screening platforms, drug dosing studies in vitro and in vivo, and clinical sample processing, including the development of patient‑derived xenograft (PDX) models.

• Design and execute CRISPR-Cas9‑based genetic screens in lung cancer cell models
• Culture and manipulate human lung cancer cell lines and organoids, including transfections and viral transductions
• Perform drug sensitivity assays in vitro and conduct dosing studies in mouse xenograft models
• Establish and maintain PDX and CDX models using immunocompromised mouse strains (NSG, NRG, athymic nude)
• Process human lung tissue specimens for downstream molecular and cellular analyses, including:
  • RNA/protein extraction
  • Flow cytometry and cell sorting
  • Single‑cell suspensions for sequencing or culture
• Operate lab equipment including Gentle
  
  MACS Cell Dissociator, flow cytometers, biosafety cabinets, and centrifuges
• Coordinate mouse studies: monitor health, measure tumor burden, maintain accurate animal records in compliance with IACUC protocols
• Prepare experimental reagents, solutions, and maintain lab stocks
• Organize and update biobank/sample databases and maintain meticulous experimental records in ELN or lab notebooks
• Assist in procurement of lab reagents and equipment; coordinate with administrative staff for ordering and service contracts

• Master of Science Degree in Life Sciences or a related field.
• 5 years of relevant lab experience, preferably in cancer biology.
• Proficiency in cell culture and standard molecular biology techniques.
• Experience handling mice, including tumor implantation and drug administration is a requirement.
• Excellent interpersonal skills, problem‑solving flexibility, and adaptability to interface with lab staff.
• Adept at planning and prioritizing work to meet commitments with a keen eye for detail.
• Action‑oriented and eager to take on new opportunities and tough challenges with a sense of urgency, high energy, and enthusiasm.

Please upload a single PDF file containing the following items by September 15, 2025
:

• Cover letter (maximum 2 pages) indicating research background, interest in the position, and expected start date
• Curriculum Vitae (CV)
• Reprints or PDFs of up to two relevant publications (if available)
• Names and contact information of three professional references

Dr. Triparna Sen
Professor, Department of Internal Medicine
Associate Director of Research, Division of Medical Oncology
Director, Preclinical Therapeutics Platform, The Ohio State University, The Arthur G. James Comprehensive Cancer Center
508 Biomedical Research Tower, 460 W 12th Ave, Columbus, OH 43210

Location:

Biomedical Research Tower (0112). Position Type:
Regular. Scheduled

Hours:

40. Shift: First Shift.

Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post‑offer process.

The university is an equal opportunity employer, including veterans and disability. As required by Ohio Revised Code section , Ohio State will: educate students by means of free, open and rigorous intellectual inquiry to seek the truth; equip students with the opportunity to develop intellectual skills to reach their own, informed conclusions; not require, favor, disfavor or prohibit speech or lawful assembly;

create a community dedicated to an ethic of civil and free inquiry, which respects the autonomy of each member, supports individual capacities for growth and tolerates differences in opinion; treat all faculty, staff and students as individuals, hold them to equal standards and provide equality of opportunity with regard to race, ethnicity, religion, sex, sexual orientation, gender identity or gender expression.