Postdoctoral Scientist

The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our major strength in understanding the immune systems of livestock provides a platform to control current diseases and respond to emerging threats.

This important research would not be possible without the proportionate use of animals, which are integral to the development of new disease control measures such as vaccines and diagnostics. We have an establishment-wide commitment to the 3

Rs (replacement, reduction and refinement), high standards of animal welfare, a culture of care and openness.

Our Institute is made up of a dynamic and vibrant community of staff covering a diverse set of chosen fields, backgrounds and experience. We all play a crucial role in furthering the Institute’s aspirations, advancing the frontiers of science and knowledge through our excellent scientific research, knowledge sharing and contribution; with a real focus in improving the world in which we live.

Our outlook is always balanced by our strong sense of purpose, values and behaviours and an unwavering commitment to a ‘one Institute’ approach.

The Postdoctoral Scientist will work in the Picornavirus Molecular Biology Group, an enthusiastic and friendly team of postdoc and student researchers. We carry out research to understand how picornaviruses enter, replicate, assemble and evolve and apply this understanding to help control picornaviruses such as foot-and-mouth disease (FMDV). The position will include research in three ongoing areas of activity in the group:
1) Restriction factors that determine FMDV host range;
2) RNA packaging signals in FMDV;
3) Mechanisms of viral entry, replication and evolution. The successful applicant will report to the Group Leader and collaborate effectively with other scientists in and beyond the group.

Working towards the objectives of the project(s)

• Carrying out laboratory based research 70%
• Developing expertise and project ownership
• Interacting with project collaborators

Communication of research findings 20%

• Writing papers and submission of work for publication
• Preparation and delivery of presentations at internal and external meetings
• Contribution to additional projects as required
• Seeking out opportunities for funding/supervising students
• Contributing to training of new staff and students as required

• A PhD or equivalent in a relevant branch of biosciences
• Experience of cell culture/virology techniques, and/or working in high containment (ideally SAPO4)
• Evidence of excellent oral and written communication skills, including the ability to communicate effectively at scientific meetings, with collaborators and in writing papers
• Evidence of working independently and as part of a team with the ability to build effective collaborative relationships
• Knowledge of picornavirus molecular virology
• Knowledge of cellular innate immunity
• Experience of molecular biology / RNA biology techniques
• Experience of microscopy, imaging plate readers or flow cytometry
• Experience of virus evolution, viral sequencing & bioinformatics
• Experience of supervising students and junior staff

Due to the nature of the work carried out by Pirbright, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances.

• Generous Group Personal Pension Scheme and life cover (subject to age and earnings)
• 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days
• Buy and sell annual leave
• Option to carry over up to two weeks annual leave
• Pirbright gym with subsidised membership
• Pirbright Lifestyle Hub (employee discount site)