Post Doc - Wolfe Lab

Position Overview

The Wolfe Laboratory will be filling a postdoctoral position to develop therapeutic genome editing reagents for muscular dystrophies and cancer. These projects will focus on:

• Development of prime editing reagents with high activity and specificity for the precise correction of common pathogenic mutations associated with Limb Girdle Muscular Dystrophy.
• Development of genome editing reagents for selective killing of cancer cells harboring gene amplifications.
• Utilization of unbiased genome-wide techniques for assessing off‑target events and other genomic alterations potentially associated with genome editing.
• Translation of the developed genome editing reagents to clinical application through in vivo safety and efficacy studies in relevant mouse models.

These studies will expose the successful candidate to cutting‑edge genome editor engineering approaches and delivery of these reagents in vivo via AAV or lipid nanoparticles. The candidate will also learn deep‑sequencing approaches to evaluate off‑target editing within the genome and will have opportunities to participate in meetings and conferences related to genome editing and gene therapy.

• Ph.D. in biology, biochemistry, chemistry, or a related biomedical science.
• Strong oral and written communication skills and eagerness to present research results at national meetings.
• Prior experience with genome editing systems, cell culture, deep‑sequencing technologies, and mouse disease models (advantageous but not required).

Applicants should send a letter (via email) describing their current research activities and interest in this position, a CV (including publications), and contact information for three references, including your Ph.D. advisor. Address letters to Scot Wolfe (scot.wolfe).

University of Massachusetts Chan Medical School
Department of Molecular, Cell and Cancer Biology
364 Plantation Street, LRB Room 619
Worcester, MA 01605

Further details about the Wolfe laboratory can be found at https://(Use the "Apply for this Job" box below). and .

The University of Massachusetts Chan Medical School welcomes all qualified applicants and complies with all state and federal anti‑discrimination laws.