Senior Scientist, Antibody Repertoire Sequencing & Discovery

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

The Biotherapeutics and Genetics Medicine department within Discovery Research is seeking a highly motivated

Senior

Scientist to join theMolecular

Coreteam at Abb Vie Bioresearch Center (ABC). The ABC site in Worcester, MA, offersaunique setting where Biotherapeuticsdiscovery, development and manufacturing coexist in one location.

The Molecular Corepartnerswith multidisciplinary groups across Abb Vie focused on developing therapies for Immunology, Neurology and Oncology diseases.

We utilize innovative approaches for antibody discovery including in vivo technologies, custom immunization strategies, advanced multiplex screening assays and best-in-class automation platforms to enable successful antibody discovery against complex targets.

• Act as scientific and technical expert inantibodyrepertoire sequencing (Rep Seq/AIRR-Seq/BCR-Seq) fortherapeuticantibody discovery and hit expansion
  
  Bulk sequencing, 10X,and other commercial and proprietary platforms.
• Collaborate withcomputationalscientists to optimizerepertoireanalysis and open new avenues forantibodydiscoverythrough repertoire guided machine learning and generative design
• Generate, document, and archive repertoire data with appropriate context and metadata to support broader team access andfutureutilization.
• Analyze and interpret results, placing data in proper scientific context through review of relevant literature, and present findings at team meetings.
• Regularly present data, communicate effectively, and coordinate work within a highly matrixed project team environment.
• Demonstrate scientific excellence through dedication to multiple projects in a fast-paced, multidisciplinary environment.
• Exhibit a can-do attitude and strong interpersonal and communication skills when working across multiple functional teams.

• BS, MS, or PhDinimmunology,molecular biology,biochemistry,bioinformaticsor a related fieldwith typically0-4+ (PhD), 8-10+ (MS), or 10-12+ (BS) yearsofrelevant experience
• Extensive scientific expertise in immunoglobulin genetics and antibody biology;specifically,the candidate should be well versed inantibody diversity generation (germline genes/V(D)
  J recombination/somatic hypermutation), affinity maturation, andB cell biology.
• Extensive technical expertiseintheisolation and molecular biology of antibody variable region genes for Next-generation Sequencing (NGS) and the capture of Rep Seq/AIRR-Seq/BCR-Seq) data; both for single-chain and paired heavy- and light-chain recovery
• Understanding ofNGS technologies and platforms Illumina (Next Seq, MiSeq) andPac Bio
• Understanding and proficiency in molecular biology techniques (e.g. PCR,primer design,molecular cloning, Gibson Assembly, plasmid design)
• Ability to improve and streamline existing processes
• Strong attention to quality and details when exercising organizational, documentation and communication skills
• Proven flexibility to deal with changing timelines and shifting work priorities
• Competency with software programs, includingantibody analysis (Pipe Bio),DNA analysis (Geneious, Se quencher) and MS Office(Excel, PowerPoint, Word)
• Fluency in computational science and familiarity withthe application ofpredictiveAI/MLtoolsand protein language models (PLMs) forantibodydiscovery

• Experience in non-human and non-murine immunogenetics
• Prior experiencewithbioinformaticsand computationalanalysis of large DNA and protein data setsis highly desired
• Experience with repertoire sequencing fromin…